Nitrosobenzene

Synonym(s):NOB

CAS NO.：586-96-9
Empirical Formula: C6H5NO
Molecular Weight: 107.11
MDL number: MFCD00002059
EINECS: 209-591-1
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is Nitrosobenzene?

Chemical properties

light yellow solid

The Uses of Nitrosobenzene

Spin trap reagent. Has been used in the study of oxidative DNA damage and nitroso-compound-induced respiratory burst in neutrophils3,4.

The Uses of Nitrosobenzene

Spin trap. Undergoes various addition, reduction, and oxidation reactions.

Definition

ChEBI: A nitroso compound that is the nitroso derivative of benzene; a diamagnetic hybrid of singlet O2 and azobenzene.

Purification Methods

Steam distil nitrosobenzene, then crystallise it from a small volume of EtOH with cooling below 0o, dry it over CaCl2 in a dessicator at atmospheric pressure, and store it under N2 at 0o. Alternatively it can be distilled onto a cold finger cooled with brine at ~-10o in a vacuum at 17mm (water pump), while heating in a water bath at 65-70o [Robertson & Vaughan J Chem Educ 27 605 1950]. [Beilstein 5 IV 702.]

Properties of Nitrosobenzene

Melting point:	65-69 °C (lit.)
Boiling point:	59 °C/18 mmHg (lit.)
Density	1.1697 (rough estimate)
refractive index	1.5389 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Solid
color	White to Brown
BRN	605688
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	586-96-9
NIST Chemistry Reference	Benzene, nitroso-(586-96-9)
EPA Substance Registry System	Nitrosobenzene (586-96-9)

Safety information for Nitrosobenzene

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.