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HomeProduct name listnifurfoline

nifurfoline

  • CAS NO.:3363-58-4
  • Empirical Formula: C13H15N5O6
  • Molecular Weight: 337.29
  • MDL number: MFCD00864944
  • EINECS: 222-131-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:37
nifurfoline Structural

What is nifurfoline?

Originator

Furobactil,Carrion,France,1974

Definition

ChEBI: Nifurfoline is an imidazolidine-2,4-dione.

Manufacturing Process

20 g of nitrofurantoin are placed in 100 cc of dimethylformamide and the solution is heated to 75°C to 80°C. This temperature is maintained and 100 cc of 40% formaldehyde are added, followed by 10 g of freshly distilled morpholine. The heating is continued for one hour, the mixture cooled and filtered and the precipitate obtained is washed with 95% alcohol. 20 g of the desired product are obtained as yellow crystals which melt at 206°C.

Therapeutic Function

Antibacterial

Properties of nifurfoline

Melting point: 206°; also reported as mp 194-196°
Boiling point: 486.5±55.0 °C(Predicted)
Density  1.63±0.1 g/cm3(Predicted)
pka 5.39±0.10(Predicted)

Safety information for nifurfoline

Computed Descriptors for nifurfoline

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