nifurfoline
- CAS NO.：3363-58-4
- Empirical Formula: C13H15N5O6
- Molecular Weight: 337.29
- MDL number: MFCD00864944
- EINECS: 222-131-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:37
What is nifurfoline?
Originator
Furobactil,Carrion,France,1974
Definition
ChEBI: Nifurfoline is an imidazolidine-2,4-dione.
Manufacturing Process
20 g of nitrofurantoin are placed in 100 cc of dimethylformamide and the solution is heated to 75°C to 80°C. This temperature is maintained and 100 cc of 40% formaldehyde are added, followed by 10 g of freshly distilled morpholine. The heating is continued for one hour, the mixture cooled and filtered and the precipitate obtained is washed with 95% alcohol. 20 g of the desired product are obtained as yellow crystals which melt at 206°C.
Therapeutic Function
Antibacterial
Properties of nifurfoline
| Melting point: | 206°; also reported as mp 194-196° |
| Boiling point: | 486.5±55.0 °C(Predicted) |
| Density | 1.63±0.1 g/cm3(Predicted) |
| pka | 5.39±0.10(Predicted) |
Safety information for nifurfoline
Computed Descriptors for nifurfoline
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