nifurfoline
- CAS NO.:3363-58-4
- Empirical Formula: C13H15N5O6
- Molecular Weight: 337.29
- MDL number: MFCD00864944
- EINECS: 222-131-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:37
What is nifurfoline?
Originator
Furobactil,Carrion,France,1974
Definition
ChEBI: Nifurfoline is an imidazolidine-2,4-dione.
Manufacturing Process
20 g of nitrofurantoin are placed in 100 cc of dimethylformamide and the solution is heated to 75°C to 80°C. This temperature is maintained and 100 cc of 40% formaldehyde are added, followed by 10 g of freshly distilled morpholine. The heating is continued for one hour, the mixture cooled and filtered and the precipitate obtained is washed with 95% alcohol. 20 g of the desired product are obtained as yellow crystals which melt at 206°C.
Therapeutic Function
Antibacterial
Properties of nifurfoline
Melting point: | 206°; also reported as mp 194-196° |
Boiling point: | 486.5±55.0 °C(Predicted) |
Density | 1.63±0.1 g/cm3(Predicted) |
pka | 5.39±0.10(Predicted) |
Safety information for nifurfoline
Computed Descriptors for nifurfoline
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
Nifuratel
Nifuradene
nifurfoline
2-FURALDEHYDE DIMETHYLHYDRAZONE
2-Furaldehyde, semicarbazone
Nifursemizone
Nitrofurazone
1-Aminohydantoin hydrochloride
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