NICLOFOLAN

CAS NO.：10331-57-4
Empirical Formula: C12H6Cl2N2O6
Molecular Weight: 345.09
MDL number: MFCD00867407
EINECS: 233-720-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is NICLOFOLAN?

Chemical properties

Orange-yellow crystalline powder. Melting point 178-182 ℃. Soluble in acetone, glacial acetic acid and sodium hydroxide solution, slightly soluble in water and ethanol.

The Uses of NICLOFOLAN

Niclofolan can be used as deworming drug and anti-creep drug. It is used for prevention and treatment of hepatic chioniasis of cattle and sheep.

Definition

ChEBI: Niclofolan is a polychlorobiphenyl.

Synthesis

Niclofolan is obtained by nitration of 5,5 '-dichloro-2, 2' dihydroxybiphenyl. The nitration was carried out in acetic acid at a temperature not exceeding 20℃. Then activated carbon was added for reflux decolorization for 1h. The filter was pumped with a nitrate filter rod. The filtrate was cooled below 15℃ and crystallized. Dinitrochlorophenol was obtained by filtration, washing with acetic acid and drying. The yield is 60%.

Properties of NICLOFOLAN

Boiling point:	251.5°C (rough estimate)
Density	1.8594 (rough estimate)
refractive index	1.7350 (estimate)
pka	4.34±0.40(Predicted)
form	Solid
color	Light yellow to yellow
EPA Substance Registry System	Niclofolan (10331-57-4)

Safety information for NICLOFOLAN

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P391:Collect spillage. Hazardous to the aquatic environment P302+P352:IF ON SKIN: wash with plenty of soap and water. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P501:Dispose of contents/container to..…