Neostigmine Methyl Sulfate
Synonym(s):3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium methyl sulfate
- CAS NO.：51-60-5
- Empirical Formula: C12H19N2O2.CH3O4S
- Molecular Weight: 334.39
- MDL number: MFCD00011796
- EINECS: 200-109-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-17 23:58:49
What is Neostigmine Methyl Sulfate?
Description
Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd = 260 μM). In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively). Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block. Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.
The Uses of Neostigmine Methyl Sulfate
Cholinergic; miotic; antidote (curare)
What are the applications of Application
Neostigmine Methyl Sulfate is a competitive inhibitor of acetylcholinesterase
Properties of Neostigmine Methyl Sulfate
| Melting point: | 175-177 °C(lit.) |
| storage temp. | -20°C |
| solubility | H2O: 1 g/mL |
| form | powder |
| color | white |
| Water Solubility | 1g/10mL |
Safety information for Neostigmine Methyl Sulfate
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H300:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P284:Wear respiratory protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P342+P311:IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
Computed Descriptors for Neostigmine Methyl Sulfate
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