H2N-PEG6-tBu
Synonym(s):tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate;H2N-PEG6-CH2CH2COOtBu
- CAS NO.:1286281-32-0
- Empirical Formula: C19H39NO8
- Molecular Weight: 409.51
- MDL number: MFCD13184944
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:08
What is H2N-PEG6-tBu?
Description
Amino-PEG6-t-butyl ester is a PEG reagent containing an amino NH2 group with a t-butyl protected carboxyl group (Boc). The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
The Uses of H2N-PEG6-tBu
This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Properties of H2N-PEG6-tBu
Boiling point: | 475.9±40.0 °C(Predicted) |
Density | 1.056±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
pka | 8.74±0.10(Predicted) |
form | Oil |
color | Colorless to light yellow |
Safety information for H2N-PEG6-tBu
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for H2N-PEG6-tBu
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