H2N-PEG8-tBu
- CAS NO.：756526-06-4
- Empirical Formula: C23H47NO10
- Molecular Weight: 497.62
- MDL number: MFCD11041142
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:13
What is H2N-PEG8-tBu?
Description
Amino-PEG8-t-butyl ester is a monodisperse PEG linker containing an amino group with a t-butyl protected carboxyl group.The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.
The Uses of H2N-PEG8-tBu
H2N-PEG8-tBu is a cleavable 8-unit PEG-ADC linker for antibody drug conjugate (ADC) synthesis.
Properties of H2N-PEG8-tBu
| Boiling point: | 544.3±45.0 °C(Predicted) |
| Density | 1.067±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Soluble in Water, DMSO, DCM, DMF |
| pka | 8.74±0.10(Predicted) |
| color | Colorless to light yellow |
Safety information for H2N-PEG8-tBu
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for H2N-PEG8-tBu
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