N-(tert-Butyl)benzylamine

CAS NO.：3378-72-1
Empirical Formula: C11H17N
Molecular Weight: 163.26
MDL number: MFCD00008798
EINECS: 222-179-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-19 15:17:17

What is N-(tert-Butyl)benzylamine?

Chemical properties

CLEAR COLOURLESS TO PALE YELLOW LIQUID

The Uses of N-(tert-Butyl)benzylamine

N-Benzyl-tert-butylamine, is used as a protected amine. It aids in the oxidation to the corresponding hydroxylamine and nitrone.

Synthesis Reference(s)

Tetrahedron Letters, 36, p. 9555, 1995 DOI: 10.1016/0040-4039(95)02046-2

Purification Methods

Dissolve the amine in Et2O, dry it over KOH pellets, filter and fractionate it in a N2 atmosphere to avoid reaction with CO2 from the air. The hydrochloride has m 245-246o(dec) (from MeOH/Me2CO) and the perchlorate has m 200-201o. [Freidfelder et al. J Am Chem Soc 80 4320 1958, Beilstein 12 IV 2166.]

Properties of N-(tert-Butyl)benzylamine

Melting point:	-25 °C
Boiling point:	80 °C5 mm Hg(lit.)
Density	0.881 g/mL at 25 °C(lit.)
vapor pressure	12.1Pa at 25℃
refractive index	n20/D 1.497(lit.)
Flash point:	176 °F
storage temp.	Store below +30°C.
solubility	2g/l
form	Oil
pka	9.77±0.29(Predicted)
color	Colourless
Water Solubility	2 g/L (20 ºC)
Sensitive	Air Sensitive
BRN	507464
Dielectric constant	3.2400000000000002
CAS DataBase Reference	3378-72-1(CAS DataBase Reference)
NIST Chemistry Reference	Benzenemethanamine, N-(1,1-dimethylethyl)-(3378-72-1)
EPA Substance Registry System	Benzenemethanamine, N-(1,1-dimethylethyl)- (3378-72-1)

Safety information for N-(tert-Butyl)benzylamine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H227:Flammable liquids H301:Acute toxicity,oral H314:Skin corrosion/irritation H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P370+P378:In case of fire: Use … for extinction. P405:Store locked up. P403+P235:Store in a well-ventilated place. Keep cool. P501:Dispose of contents/container to..…