N-Phenyl-bis(trifluoromethanesulfonimide)

Synonym(s):N,N-Bis(trifluoromethylsulfonyl)aniline;N-Phenyl-trifluoromethanesulfonimide;1,1,1-Trifluoro-N-phenyl-N-[(trifluoromethyl)sulfonyl]methanesulfonamide;NSC 240874;Phenyl triflimide

CAS NO.：37595-74-7
Empirical Formula: C8H5F6NO4S2
Molecular Weight: 357.25
MDL number: MFCD00000404
EINECS: 609-445-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-25 09:47:11

N-Phenyl-bis(trifluoromethanesulfonimide) Structural

What is N-Phenyl-bis(trifluoromethanesulfonimide)?

The Uses of N-Phenyl-bis(trifluoromethanesulfonimide)

N-Phenylbis(trifluoromethanesulfonamide) is used in the enantioselective synthesis of β-amino acids via the Mannich reaction. Used in the synthesis of sphingosine 1-phosphate-1 receptor agonists usefu l in pharmaceutical application.

The Uses of N-Phenyl-bis(trifluoromethanesulfonimide)

N-Phenyl-bis(trifluoromethanesulfonimide)
To a solution of the SM (798 mg, 3.14 mmol) in DCM (7 mL) was added DMAP (38.3 mg, 0.314 mmol), TEA (1.31 mL, 9.41 mmol), and Tf2NPh (1.68 g, 4.71 mmol). The reaction mixture was stirred at RT for 90 min, after which time it was concentrated in vacuo. The resulting material was purified by Prep LC (50 g silica, 0-20% EtOAc/heptane) to provide the product as a yellow oil which crystallized upon standing. [1.17 g, 97%]

Properties of N-Phenyl-bis(trifluoromethanesulfonimide)

Melting point:	100-102 °C(lit.)
Boiling point:	305.3±52.0 °C(Predicted)
Density	1.766±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in methanol. Slightly soluble in chloroform and ethyl acetate.
form	Crystals or Crystalline Powder
color	White or colorless
Sensitive	Moisture Sensitive

Safety information for N-Phenyl-bis(trifluoromethanesulfonimide)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.