N'-Nitro-L-arginine
Synonym(s):L -NNA;N5-(Nitroamidino)-L -2,5-diaminopentanoic acid;NG-NO2-L -Arg
- CAS NO.：2149-70-4
- Empirical Formula: C6H13N5O4
- Molecular Weight: 219.2
- MDL number: MFCD00007033
- EINECS: 218-418-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:35
What is N'-Nitro-L-arginine?
Chemical properties
WHITE TO OFF-WHITE POWDER
The Uses of N'-Nitro-L-arginine
Nω-Nitro-L-arginine is an inhibitor for nitric oxide synthase and is used in the study of bacterium to determine effective treatments. Used in the study of MRSA (Methicillin-Resistant Staphylococcus Aureus).
What are the applications of Application
N G-Nitro-L-arginine is an inhibitor of NOS with selectivity for NOS1 and NOS3
Definition
ChEBI: N(gamma)-nitro-L-arginine is an L-arginine derivative that is L-arginine in which the terminal nitrogen of the guanidyl group is replaced by a nitro group. It is a L-arginine derivative, a N-nitro compound, a member of guanidines and a non-proteinogenic L-alpha-amino acid.
Hazard
A reproductive hazard.
Biological Activity
NO synthase inhibitor.
Biochem/physiol Actions
Nω-Nitro-L-arginine/L-NNA helps to reduce the levels of cortical hyperemia and brain cGMP occurring due to hypercapnia.
Safety Profile
Experimental reproductiveeffects. When heated to decomposition it emits toxicvapors of NOx.
Properties of N'-Nitro-L-arginine
| Melting point: | 257 °C (dec.)(lit.) |
| Boiling point: | 360°C (rough estimate) |
| alpha | 23.5 º (c=4, 2N HCl 24 ºC) |
| Density | 1.4177 (rough estimate) |
| RTECS | RM2982100 |
| refractive index | 1.8000 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMF: <50 μg/ml; DMSO: <50 μg/ml; Ethanol: <50 μg/ml; PBS pH 7.2: 1 mg/ml |
| pka | 2.49±0.24(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | Soluble to 5 mM in water |
| BRN | 1728914 |
| CAS DataBase Reference | 2149-70-4(CAS DataBase Reference) |
| EPA Substance Registry System | L-Ornithine, N5-[imino(nitroamino)methyl]- (2149-70-4) |
Safety information for N'-Nitro-L-arginine
Computed Descriptors for N'-Nitro-L-arginine
| InChIKey | MRAUNPAHJZDYCK-BYPYZUCNSA-N |
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