N-Methyl-2,2,2-trifluoroacetamide

CAS NO.：815-06-5
Empirical Formula: C3H4F3NO
Molecular Weight: 127.07
MDL number: MFCD00009670
EINECS: 212-417-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-16 16:23:18

What is N-Methyl-2,2,2-trifluoroacetamide?

Chemical properties

WHITE CRYSTALS OR CRYSTALLINE POWDER

The Uses of N-Methyl-2,2,2-trifluoroacetamide

N-Methyltrifluoroacetamide is a useful synthetic intermediate. It is used to prepare electrophilic 11b-aryl derivs. of estradiol as steroidal affinity labels of the estrogen receptor a. It is also used to synthesize amino substituted derivatives of 5'-amino-5'-deoxy-5'-noraristeromycin as antiviral agent.

General Description

The high-resolution proton and fluorine resonance spectra of N-methyltrifluoroacetamide in tetrahydrofuran and acetone was studied.

Properties of N-Methyl-2,2,2-trifluoroacetamide

Melting point:	49-51 °C(lit.)
Boiling point:	156-157 °C(lit.)
Density	1.3215 (estimate)
Flash point:	165 °F
storage temp.	Inert atmosphere,Room Temperature
form	powder to crystal
pka	11.54±0.46(Predicted)
color	White to Almost white
Sensitive	Hygroscopic
BRN	1703392
InChI	InChI=1S/C3H4F3NO/c1-7-2(8)3(4,5)6/h1H3,(H,7,8)
CAS DataBase Reference	815-06-5(CAS DataBase Reference)
NIST Chemistry Reference	Acetamide, 2,2,2-trifluoro-N-methyl-(815-06-5)
EPA Substance Registry System	Acetamide, 2,2,2-trifluoro-N-methyl- (815-06-5)

Safety information for N-Methyl-2,2,2-trifluoroacetamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.