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HomeProduct name list2-mercapto-N-methylbenzamide

2-mercapto-N-methylbenzamide

  • CAS NO.:20054-45-9
  • Empirical Formula: C8H9NOS
  • Molecular Weight: 167.23
  • MDL number: MFCD00136334
  • EINECS: 633-825-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-05 12:01:54
2-mercapto-N-methylbenzamide Structural

What is 2-mercapto-N-methylbenzamide?

Description

N-methyl-2-sulfanylbenzamide is an axitinib intermediate.

The Uses of 2-mercapto-N-methylbenzamide

2-Mercapto-N-methyl-benzamide is an intermediate used to prepare axitinib (A794650) which is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

What are the applications of Application

2-Mercapto-N-methyl-benzamide is an intermediate used to prepare axitinib which is a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Synthesis

2-mercapto-N-methylbenzamide is prepared by reactig 2,2'-Disulfanediylbis(N-methylbenzamide) and sodium tetrahydroborate In tetrahydrofuran.2-mercapto-N-methylbenzamide

Properties of 2-mercapto-N-methylbenzamide

Melting point: 94-96 °C
Boiling point: 326.2±25.0 °C(Predicted)
Density  1.174
storage temp.  2-8°C
solubility  Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
pka 5.89±0.43(Predicted)
form  Solid
color  Off-White to Pale Beige
Stability: Air Sensitive

Safety information for 2-mercapto-N-methylbenzamide

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H317:Sensitisation, Skin
H318:Serious eye damage/eye irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P272:Contaminated work clothing should not be allowed out of the workplace.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501:Dispose of contents/container to..…

Computed Descriptors for 2-mercapto-N-methylbenzamide

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