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HomeProduct name list6-Nitroindazole

6-Nitroindazole

  • CAS NO.:7597-18-4
  • Empirical Formula: C7H5N3O2
  • Molecular Weight: 163.13
  • MDL number: MFCD00005695
  • EINECS: 231-500-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-09-02 13:12:44
6-Nitroindazole Structural

What is 6-Nitroindazole?

Description

6-Nitroindazole is a competitive and reversible Monoamine oxidase(MAO)inhibitor. It can inhibit MAO-A and MAO-B (IC50= 2.5 μM). Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models. In addition, it is an nNOS inhibitor, which has neuroprotective effects[1].

Chemical properties

yellow powder

The Uses of 6-Nitroindazole

Anticonvulsant.

The Uses of 6-Nitroindazole

Anticonvulsant

What are the applications of Application

6-Nitroindazole is an anticonvulsant

Synthesis

6-Nitroindazole is prepared by (2-methyl-5-nitrophenyl)azo phenyl sulfide and 1,8-diazabicyclo[5.4.0]undec-7-ene in the presence of concentrated  acetonitrile.6-Nitroindazole

References

[1] HERRAIZTOMAS  GuillénHugo  AránVicente J. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).[J]. Free Radical Research, 2009: 975-984. DOI:10.1080/10715760903159170.

Properties of 6-Nitroindazole

Melting point: 180-182 °C (lit.)
Boiling point: 290.19°C (rough estimate)
Density  1.4141 (rough estimate)
refractive index  1.5500 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  very faint turbidity in hot Methanol
form  Powder
pka 11.08±0.40(Predicted)
color  Light Yellow
BRN  7812
CAS DataBase Reference 7597-18-4(CAS DataBase Reference)
NIST Chemistry Reference 6-Nitroindazole(7597-18-4)
EPA Substance Registry System 1H-Indazole, 6-nitro- (7597-18-4)

Safety information for 6-Nitroindazole

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
H351:Carcinogenicity
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for 6-Nitroindazole

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