N-Isopropylaniline

CAS NO.：768-52-5
Empirical Formula: C9H13N
Molecular Weight: 135.21
MDL number: MFCD00026347
EINECS: 212-196-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:52

What is N-Isopropylaniline?

Chemical properties

Clear light yellow liquid

The Uses of N-Isopropylaniline

N-Isopropylaniline is a microbial metabolite of Propachlor (P757300), an acylanilide herbicide that is used to maintain crop protection from weeds. Propachlor is also known to induce Glutathione (G597951)-dependent cytotoxicity and sister chromatid exchanges in human cells.

The Uses of N-Isopropylaniline

Dyeing of acrylic fibers and as a chemical intermediate

Synthesis Reference(s)

The Journal of Organic Chemistry, 28, p. 3259, 1963 DOI: 10.1021/jo01046a537
Tetrahedron, 52, p. 9777, 1996 DOI: 10.1016/0040-4020(96)00503-0

General Description

N-isopropylaniline is a clear brown liquid. (NTP, 1992)

Air & Water Reactions

Insoluble in water.

Reactivity Profile

N-Isopropylaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Toxic by inhalation and skin absorption.

Health Hazard

N-isopropylaniline absorption causes methemoglobinemia in animals, and the same effect is expected in humans.

Fire Hazard

N-Isopropylaniline is combustible.

Properties of N-Isopropylaniline

Melting point:	-32°C
Boiling point:	55 °C0.3 mm Hg(lit.)
Density	0.934 g/mL at 25 °C(lit.)
refractive index	n20/D 1.539(lit.)
Flash point:	185 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	5.77(at 25℃)
form	Liquid
Specific Gravity	0.94
color	Colorless to Orange to Green
Water Solubility	<0.01 g/100 mL at 21 ºC
BRN	2205871
Exposure limits	ACGIH: TWA 2 ppm (Skin) NIOSH: IDLH 100 ppm; TWA 2 ppm(10 mg/m3)
CAS DataBase Reference	768-52-5(CAS DataBase Reference)
NIST Chemistry Reference	N-Isopropylaniline(768-52-5)
EPA Substance Registry System	N-Isopropylaniline (768-52-5)

Safety information for N-Isopropylaniline

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H227:Flammable liquids H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H330:Acute toxicity,inhalation H331:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P284:Wear respiratory protection. P310:Immediately call a POISON CENTER or doctor/physician. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.