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HomeProduct name listN-(Hydroxymethyl)phthalimide

N-(Hydroxymethyl)phthalimide

Synonym(s):N-(Hydroxymethyl)-phthalimide;Phthalimidomethanol

  • CAS NO.:118-29-6
  • Empirical Formula: C9H7NO3
  • Molecular Weight: 177.16
  • MDL number: MFCD00005899
  • EINECS: 204-241-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-21 22:41:43
N-(Hydroxymethyl)phthalimide Structural

What is N-(Hydroxymethyl)phthalimide?

Chemical properties

white crystalline powder

The Uses of N-(Hydroxymethyl)phthalimide

N-(Hydroxymethyl)phthalimide is used as a reactant in the synthesis of 5-[(3-aralkyl amido/imidoalkyl)phenyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as antiviral agents.

The Uses of N-(Hydroxymethyl)phthalimide

For amidomethylation of aromatics in triflic acid.

Definition

ChEBI: A primary alcohol comprising phthalimide carrying an N-hydroxymethyl substituent.

Preparation

To a flask equipped with a mechanical stirrer and condenser is added 511 gm (3.47 moles) of phthalimide, 260 ml of 40% formalin (3.47 moles), and 1750 ml of water. The mixture is refluxed for about 5-10 min or until a clear solution results (if any insoluble material remains, it is first filtered). Then the mixture is cooled for several hours. The resulting product is filtered with suction, washed with cold water, and air-dried to afford 594 gm (96%), m.p. 137-141°C.
NOTE: The product should not be oven-dried since it decomposes with the loss of formaldehyde. Recrystallization of the product from ethanol affords 94% recovery of the original material with the same melting point range.
Preparation of N-Hydroxymethylphthalimide

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 1913, 1955 DOI: 10.1021/ja01612a068

Properties of N-(Hydroxymethyl)phthalimide

Melting point: 147-149 °C (lit.)
Boiling point: 309.06°C (rough estimate)
Density  1.3312 (rough estimate)
refractive index  1.5200 (estimate)
storage temp.  Store below +30°C.
form  Fine Crystalline Powder
pka 13.17±0.10(Predicted)
color  White
BRN  140946
CAS DataBase Reference 118-29-6(CAS DataBase Reference)
NIST Chemistry Reference 1H-isoindole-1,3(2h)-dione, 2-(hydroxymethyl)-(118-29-6)
EPA Substance Registry System N-(Hydroxymethyl)phthalimide (118-29-6)

Safety information for N-(Hydroxymethyl)phthalimide

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for N-(Hydroxymethyl)phthalimide

InChIKey MNSGOOCAMMSKGI-UHFFFAOYSA-N

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