N-(Hydroxymethyl)phthalimide
Synonym(s):N-(Hydroxymethyl)-phthalimide;Phthalimidomethanol
- CAS NO.:118-29-6
- Empirical Formula: C9H7NO3
- Molecular Weight: 177.16
- MDL number: MFCD00005899
- EINECS: 204-241-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is N-(Hydroxymethyl)phthalimide?
Chemical properties
white crystalline powder
The Uses of N-(Hydroxymethyl)phthalimide
N-(Hydroxymethyl)phthalimide is used as a reactant in the synthesis of 5-[(3-aralkyl amido/imidoalkyl)phenyl]-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines as antiviral agents.
The Uses of N-(Hydroxymethyl)phthalimide
For amidomethylation of aromatics in triflic acid.
Definition
ChEBI: A primary alcohol comprising phthalimide carrying an N-hydroxymethyl substituent.
Preparation
To a flask equipped with a mechanical stirrer and condenser is added 511 gm (3.47 moles) of phthalimide, 260 ml of 40% formalin (3.47 moles), and 1750 ml of water. The mixture is refluxed for about 5-10 min or until a clear solution results (if any insoluble material remains, it is first filtered). Then the mixture is cooled for several hours. The resulting product is filtered with suction, washed with cold water, and air-dried to afford 594 gm (96%), m.p. 137-141°C.
NOTE: The product should not be oven-dried since it decomposes with the loss of formaldehyde. Recrystallization of the product from ethanol affords 94% recovery of the original material with the same melting point range.
Synthesis Reference(s)
Journal of the American Chemical Society, 77, p. 1913, 1955 DOI: 10.1021/ja01612a068
Properties of N-(Hydroxymethyl)phthalimide
Melting point: | 147-149 °C (lit.) |
Boiling point: | 309.06°C (rough estimate) |
Density | 1.3312 (rough estimate) |
refractive index | 1.5200 (estimate) |
storage temp. | Store below +30°C. |
form | Fine Crystalline Powder |
pka | 13.17±0.10(Predicted) |
color | White |
BRN | 140946 |
CAS DataBase Reference | 118-29-6(CAS DataBase Reference) |
NIST Chemistry Reference | 1H-isoindole-1,3(2h)-dione, 2-(hydroxymethyl)-(118-29-6) |
EPA Substance Registry System | N-(Hydroxymethyl)phthalimide (118-29-6) |
Safety information for N-(Hydroxymethyl)phthalimide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for N-(Hydroxymethyl)phthalimide
InChIKey | MNSGOOCAMMSKGI-UHFFFAOYSA-N |
Abamectin manufacturer
Rivashaa Agrotech Biopharma Pvt. Ltd.
Bhakti Impex
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