N-Boc-L-tert-Leucine

Synonym(s):(S)-N-Boc-2-amino-3,3-dimethylbutyric acid;Boc-L-tert-leucine;Boc-L-α-t-butylglycine;N-α-t.-Boc-L-α-t.-butyl-glycine,N-α-t.-Boc-L-t-leucine

CAS NO.：62965-35-9
Empirical Formula: C11H21NO4
Molecular Weight: 231.29
MDL number: MFCD00065574
EINECS: 613-118-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-02-06 18:17:50

What is N-Boc-L-tert-Leucine?

Description

N-Boc-L-tert-Leucine is a white to slightly yellow crystalline powder. The carboxyl group in its structure can be condensed with alcohol compounds under the catalysis of acid or base to obtain the corresponding ester derivatives. This substance can be used for the synthesis of amino acid drugs due to the various chemical transformation properties of its amine and carboxyl groups. The Boc protective group is able to protect the amino group of the amino acid from non-specific reactions with other reactants. This compound is a derivative of L-tert-Leucine, which is a non-polar amino acid. Its tert-butyl group exhibits significant hydrophobicity and steric hindrance, enabling effective control of molecular conformation in chemical reactions, leading to the formation of chiral compounds. As a crucial chiral intermediate, L-tert-leucine is widely employed in the synthesis of anti-cancer, anti-viral, and biological inhibitors. Additionally, L-tert-leucine serves as an essential additive in the food and cosmetic industry.

Chemical properties

White crystalline powder

The Uses of N-Boc-L-tert-Leucine

Atazanavir Related Compound A

Properties of N-Boc-L-tert-Leucine

Melting point:	118-121 °C
alpha	-4.2 º (c=1% in glacial acetic acid)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Crystalline Powder
color	White to slightly yellow
optical activity	[α]20/D 4.2±0.5°, c = 1% in glacial acetic acid
BRN	1962763
InChI	InChI=1/C11H21NO4/c1-10(2,3)7(8(13)14)12-9(15)16-11(4,5)6/h7H,1-6H3,(H,12,15)(H,13,14)/t7-/s3
CAS DataBase Reference	62965-35-9(CAS DataBase Reference)

Safety information for N-Boc-L-tert-Leucine

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H290:Corrosive to Metals H314:Skin corrosion/irritation
Precautionary Statement Codes	P234:Keep only in original container. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P390:Absorb spillage to prevent material damage. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P405:Store locked up. P406:Store in corrosive resistant/… container with a resistant inner liner.