N-Boc-2-piperidone
- CAS NO.：85908-96-9
- Empirical Formula: C10H17NO3
- Molecular Weight: 199.25
- MDL number: MFCD02179046
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-25 10:55:07
What is N-Boc-2-piperidone?
Chemical properties
Off-White Low Melting Solid
The Uses of N-Boc-2-piperidone
Intermediate in the preparation of various biological inhibitors.
What are the applications of Application
1-N-Boc-2-piperidone is a useful boc protected biochemical for proteomics research
Definition
ChEBI:N-Boc-2-piperidone-protected by t-Boc. It is also known as 1-N-Boc-2-piperidone,1-N-Boc-2-piperidone, or 1-(tert-Butoxycarbonyl)-2-piperidone.
Preparation
4-Benzensulfonylmethyl-4-hydroxy-piperidine TFA (B-1) Diisopropylethylamine (28.3 mL, 162.75 mmol) and di-t-butyl dicarbonate (28.4 g, 130.02 mmol) were added in sequence to a mixture of piperidone hydrate hydrochloride (12) (10.0 g, 65.1 mmol) in methanol (50 mL). The mixture was stirred at room temperature for 20 hours. After that, removed the solvent and the remaining was separated with ether and 1 M KHSO4 solution. The organic layer was washed with brine and saturated NaHCO3. Finally, N-Boc-2-piperidone was obtained after purification.
Properties of N-Boc-2-piperidone
| Melting point: | 29-36 °C |
| Boiling point: | 110°C/0.1mmHg(lit.) |
| Density | 1.099±0.06 g/cm3(Predicted) |
| Flash point: | >110 °C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| form | Solid |
| pka | -2.29±0.20(Predicted) |
| color | Off-White Low Melting |
| BRN | 4674955 |
| InChI | InChI=1S/C10H17NO3/c1-10(2,3)14-9(13)11-7-5-4-6-8(11)12/h4-7H2,1-3H3 |
| CAS DataBase Reference | 85908-96-9(CAS DataBase Reference) |
Safety information for N-Boc-2-piperidone
| Signal word | Warning |
| Pictogram(s) |
 Environment GHS09 |
| GHS Hazard Statements |
H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P501:Dispose of contents/container to..… |
Computed Descriptors for N-Boc-2-piperidone
| InChIKey | ULMHMJAEGZPQRY-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCCCC1=O |
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