N-acetyl aspartyl-glutaMic acid
Synonym(s):NAAG;NAAG - CAS 3106-85-2 - Calbiochem;N-Acetyl-Asp-Glu, N-acetylaspartylglutamate;Spaglumic acid;Spaglumic acid
- CAS NO.：3106-85-2
- Empirical Formula: C11H16N2O8
- Molecular Weight: 304.25
- MDL number: MFCD00076652
- EINECS: 628-471-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-11 15:28:25
What is N-acetyl aspartyl-glutaMic acid?
Chemical properties
White powder
The Uses of N-acetyl aspartyl-glutaMic acid
N-acetyl aspartyl-glutamic acid is a spaglumic acid is a marker of neuronal integrity and was used in the detection of therapeutic values of antidrepressant treatments.
The Uses of N-acetyl aspartyl-glutaMic acid
N-Acetyl-Asp-Glu has been used in N-acetylated α-linked acidic dipeptidase (NAALADase) assay and affinity experiments.
What are the applications of Application
N-Acetyl-Asp-Glu-OH is an endogenous neurotransmitter with high affinity for mGluR-3
Definition
ChEBI: A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage.
General Description
NAAG is a neuropeptide and a neurotransmitter that is abundant in the mammalian nervous system. It remains uncertain whether this compound activates NMDA receptors; however, it is clearly demonstrated to act as a selective agonist of mGluR3, both in vitro and in vivo.
Biochem/physiol Actions
Endogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR3. It is an antagonist at NMDA receptors. Catabolized by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate.
storage
-20°C
Properties of N-acetyl aspartyl-glutaMic acid
| Melting point: | 171-173 °C |
| Boiling point: | 769.5±60.0 °C(Predicted) |
| Density | 1.472±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL |
| form | powder |
| pka | 3.04±0.10(Predicted) |
| color | white |
| optical activity | [α]22/D 34.5°, c = 1.1 in H2O(lit.) |
| Water Solubility | Soluble to 100 mM in water |
| Stability: | Hygroscopic |
Safety information for N-acetyl aspartyl-glutaMic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-acetyl aspartyl-glutaMic acid
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![NAAG, [GLUTAMATE-3,4-3H]-](https://img.chemicalbook.in/StructureFile/ChemBookStructure2/GIF/CB1464605.gif)
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