Isobutyramide

Chemical properties

white needle-like crystalline powder

The Uses of Isobutyramide

Isobutyramide could be a useful compound for technical applications as a component in environmentally-friendly automobile welding anti-spatter liquid.

The Uses of Isobutyramide

Isobutyramide plays an important role in chemical grafting of human serum albumin during the synthesis of sequentially assembled protein capsules. It is used in pharmaceutical manufacturing and in cellular differentiation. It finds application in the transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene. Further, it is in the treatment of beta-thalassemia and sickle cell disease.

What are the applications of Application

Isobutyramide is activates transcription of human γ-globin gene and murine embryonic epsilon(y)-globin gene

What are the applications of Application

Isobutyramide was used for chemical grafting of human serum albumin during the synthesis of sequentialy assembled protein capsules.
Isobutyramide plays an important role in chemical grafting of human serum albumin during the synthesis of sequentially assembled protein capsules. It is used in pharmaceutical manufacturing and in cellular differentiation. It finds application in the transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene. Further, it is in the treatment of beta-thalassemia and sickle cell disease.

Definition

ChEBI: Isobutyramide is a carboximidic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 69, p. 2058, 1947 DOI: 10.1021/ja01200a070

Biochem/physiol Actions

Isobutyramide activates transcription of human gamma-globin gene and murine embryonic epsilon(y)-globin gene. It is useful in the treatment of β-thalassemia and sickle cell disease.

Purification Methods

Crystallise the amide from acetone, *benzene, CHCl3, EtOAc or water, then dry it under vacuum over P2O5 or 99% at H2SO4, or at 70o/3hours in a desiccator. Sublime it under vacuum. [Kent & McAlvain Org Synth Coll Vol III 491 1955, Beilstein 2 H 293, 2 I 129, 2 II 262, 2 III 654, 2 IV 852.]