N-Acetyl-4-piperidone

CAS NO.：32161-06-1
Empirical Formula: C7H11NO2
Molecular Weight: 141.17
MDL number: MFCD00006190
EINECS: 250-937-6
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is N-Acetyl-4-piperidone?

Chemical properties

clear orange oily liquid

The Uses of N-Acetyl-4-piperidone

1-Acetyl-4-piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs, and manufacture of fentanyl.

Purification Methods

Purify it by fractional distillaton through a short Vigreux column (15mm, p 11). The 2,4-dinitrophenylhydrazone has m 212-213o (from EtOH). It is freely soluble in H2O but insoluble in Et2O. [McElvain & McMahon J Am Chem Soc 71 901 1949, Beilstein 21/6 V 246.]

Properties of N-Acetyl-4-piperidone

Boiling point:	218 °C(lit.)
Density	1.146 g/mL at 25 °C(lit.)
refractive index	n20/D 1.503(lit.)
Flash point:	>230 °F
storage temp.	Inert atmosphere,Room Temperature
form	Oily Liquid
pka	-0.72±0.20(Predicted)
Specific Gravity	1.16
color	Clear orange
Water Solubility	Soluble in water. Insoluble in acetic acid.
BRN	116031
CAS DataBase Reference	32161-06-1(CAS DataBase Reference)
NIST Chemistry Reference	1-Acetyl-4-piperidone(32161-06-1)

Safety information for N-Acetyl-4-piperidone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.