N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide

CAS NO.：90357-51-0
Empirical Formula: C12H9F3N2O2
Molecular Weight: 270.21
MDL number: MFCD08460201
EINECS: 618-536-4
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:38

What is N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide?

The Uses of N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide

N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyl-2-oxiranecarboxamide, is an intermediate in synthesis of more complex pharmaceutical compounds. It is used in the synthesis of potential impurities of Bicalutamide (B382000), which is an oral nonsteroidal, anti-androgen drug used for prostate cancer.

Properties of N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide

Melting point:	151-152 °C
Boiling point:	436.4±45.0 °C(Predicted)
Density	1.42±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	12.08±0.70(Predicted)
color	White to Off-White
CAS DataBase Reference	90357-51-0(CAS DataBase Reference)

Safety information for N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.