N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
- CAS NO.：444731-75-3
- Empirical Formula: C14H14ClN5
- Molecular Weight: 287.75
- MDL number: MFCD12923006
- EINECS: 810-050-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-03-10 17:18:44
What is N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine?
Chemical properties
Light Beige to Beige Solid
The Uses of N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
Synthesis
A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).
Properties of N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
| Melting point: | 167-173℃ |
| Boiling point: | 524.4±35.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly) |
| pka | 2.82±0.30(Predicted) |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 444731-75-3 |
Safety information for N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
New Products
4-Piperidinemethanol Ethyl 2,4-Dihydroxy-6-methylnicotinate Ethyl isonicotinate 3-pyridine methanol N-Methyl 4-chloro-pyridine-2-carboxamide 2-Fluoro-6-iodobenzoic acid 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-((dimethylamino)methyl)-5-(4-nitrophenyl)thiophene-3-carboxylic acid Ethyl2-oxo-2,3,9,10-tetrahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline-8(7H)-carboxylate Elinzanetant tert-butyl 2-(4-amino-6-chloropyrimidin-5-yloxy)ethylmethylcarbamate Phenylazomalononitrile 5,6 Dimethoxy-1-indanone 3-Iodophenylacetic acid 2-Hexyn-1-ol Dibenzo-18-crown-6 2-Propanamine, 1-chloro-, hydrochloride (9CI) 3-Pyridineacetonitrile, α-hydroxy- 3-(hexyloxy)-4-(pyridin-3-yl)-1,2,5-thiadiazole N Ethylmethylamine Ethyl Methanesulfonate N N' DimethylEthylenediamine Lead II Bromide Variamine Blue B Diazonium salt N N N'Trimethyl ethylenediamineRelated products of tetrahydrofuran
![5-[[4-[(2,3-DiMethyl-2H-indazol-6-yl)aMino]-2-pyriMidinyl]aMino]-2-MethylbenzenesulfonaMide](https://img.chemicalbook.in/CAS/GIF/1252927-47-1.gif)
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