N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
- CAS NO.：444731-75-3
- Empirical Formula: C14H14ClN5
- Molecular Weight: 287.75
- MDL number: MFCD12923006
- EINECS: 810-050-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-13 11:39:26
What is N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine?
Chemical properties
Light Beige to Beige Solid
The Uses of N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
N-(2-Chloro-4-pyrimidinyl)-N,2,3-trimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
Synthesis
A flask was charged with N,2,3-trimethyl-2H-indazol-6-amine (1 eq.), 2,4-dichloropyrimidine (1.5 eq.), sodium bicarbonate (2 eq.) and N, N-dimethylformamide. The reaction mixture was stirred at 85 °C until completion of the reaction. Then, water was added and stirred for 3 h. Product crystals were collected by filtration, washed with water, and then dried to get N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine as off-white/beige powder (Yield: 97%).
Properties of N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
| Melting point: | 167-173℃ |
| Boiling point: | 524.4±35.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly) |
| pka | 2.82±0.30(Predicted) |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 444731-75-3 |
Safety information for N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
Abamectin manufacturer
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ANAXLABORATORIES PRIVATE LIMITED
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product: Pazopanib ( PAZ ) N - Methyl compound 444731-75-3 98%
Vidgas science and technologies Pvt Ltd
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Synergene Active Ingredients Pvt. Ltd.
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