N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
- CAS NO.:444731-74-2
- Empirical Formula: C13H12ClN5
- Molecular Weight: 273.72
- MDL number: MFCD17014818
- EINECS: 810-051-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-01 10:36:07
What is N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine?
The Uses of N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine is an impurity of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
What are the applications of Application
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine is a valuable organic compound that could be used to synthesize N-(2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, N- (2-chloropyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-amine, and others.
Synthesis
2,3-dimethyl-6-amino-2H- indazole 5.00g,2,4-Dichloropyrimidine 13.9g and sodium bicarbonate 10.4g were dissolved in 100mL absolute ethanol and heated to 79°C.After refluxing for 4 h, cool to room temperature and filter. The cake was washed well with ethyl acetate, and the filtrate was collected. Concentrate under reduced pressure, remove the solvent, and fully beat with ethyl acetate and filter to give an off-white solid. Recrystallization from methanol gave 7.64 g of product N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine as a white solid, yield: 90.0%.
Properties of N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
Melting point: | >216oC (dec.) |
Boiling point: | 550.0±35.0 °C(Predicted) |
Density | 1.41±0.1 g/cm3(Predicted) |
storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 2.56±0.30(Predicted) |
color | Pale Orange to Light Brown |
Stability: | Hygroscopic |
Safety information for N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
Computed Descriptors for N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine
Abamectin manufacturer
SYNARTIS PHARMA PVT LTD
VGS SYNTHESIS PRIVATE LIMITED
Vidgas science and technologies Pvt Ltd
ALS INDIA LIFE SCIENCES
Kekule Pharma Limited
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