N-(2-Aminoethyl)piperidine
Synonym(s):2-Piperidinoethylamine
- CAS NO.:27578-60-5
- Empirical Formula: C7H16N2
- Molecular Weight: 128.22
- MDL number: MFCD00006516
- EINECS: 248-540-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is N-(2-Aminoethyl)piperidine?
Chemical properties
CLEAR COLOURLESS TO YELLOW LIQUID
The Uses of N-(2-Aminoethyl)piperidine
1-(2-Aminoethyl)piperidine is used in modification of vinylbenzyl chloride/divinylbenzene gel copolymer bead and in the synthesis of linkage isomers trans-bis[1-(2-aminoethyl)piperidine]dinitronickel and trans-bis[1-(2-aminoethyl)-piperidine]dinitritonickel. It is also used as a reactant for synthesis of: analogs of anticancer agents, inhibitor of botulinum neurotoxin serotype A light chain, P. falciparum malaria, and Ebola filovirus, cannabinoid CB1 receptor antagonists, small molecules that restore E-cadherin expression and reduce invasion in colorectal carcinoma cells, potent and selective 5-HT6 antagonists and N-mustards as anticancer agents. 1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.
General Description
1-(2-Aminoethyl)piperidine on [1+1] condensation reaction with 3-methoxy salicylaldehyde yields tridentate Schiff base ligand.
Properties of N-(2-Aminoethyl)piperidine
Melting point: | 67-70 °C(Solv: ligroine (8032-32-4); dichloromethane (75-09-2)) |
Boiling point: | 186 °C(lit.) |
Density | 0.899 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | 136 °F |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
form | Liquid |
pka | pK1: 6.38;pK2: 9.89 (30°C) |
color | Clear colorless to yellow |
Water Solubility | Partly miscible in water. |
Sensitive | Air Sensitive |
BRN | 103469 |
CAS DataBase Reference | 27578-60-5(CAS DataBase Reference) |
NIST Chemistry Reference | 1-Piperidineethanamine(27578-60-5) |
Safety information for N-(2-Aminoethyl)piperidine
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H226:Flammable liquids H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-(2-Aminoethyl)piperidine
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