morpholin-3-one
- CAS NO.:109-11-5
- Empirical Formula: C4H7NO2
- Molecular Weight: 101.1
- MDL number: MFCD00631009
- EINECS: 203-647-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is morpholin-3-one?
Description
3-ketomorpholine is also known as morpholin-3-one. It is useful pharmacological intermediate. Recent studies have shown that some morpholin-3-one derivatives could effectively cause cell cycle arrest at G1 phase, increase the levels of P53 and Fas, and induce A549 cell apoptosis in lung cancer. This indicates it might be a useful tool for elucidating the molecular mechanism of lung cancer cell apoptosis and might also be potential anti-cancer drugs. Some of its derivatives have been proven to be useful for the prevention and treatment of arteriosclerosis and hypertriglyceridemia.
The Uses of morpholin-3-one
3-Morpholinone is used as a reactant in the synthesis of 3-Morpholinone derivates. An example of this is 4-(4-Aminophenyl)-3-morpholinone, the key intermediate in the synthesis of Rivaroxaban (an anticoagulant).
References
He, Q., et al. "Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells." Bioorganic & Medicinal Chemistry 15.11(2007): 3889.
Murai, Hiromu, et al. "Morpholinone derivatives and method of use." US, US4237132. 1980.
Gonzalez-garcia, Maria Rosario, and Fernandez, Maria Carmen. "Morpholinyl derivatives useful as MOGAT-2 inhibitors." (2015).
Properties of morpholin-3-one
Melting point: | 103.0 to 107.0 °C |
Boiling point: | 142°C/7mmHg(lit.) |
Density | 1.122±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | soluble in Methanol |
form | powder to crystal |
pka | 14.37±0.20(Predicted) |
color | White to Almost white |
CAS DataBase Reference | 109-11-5(CAS DataBase Reference) |
EPA Substance Registry System | 3-Morpholinone (109-11-5) |
Safety information for morpholin-3-one
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H318:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for morpholin-3-one
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