morclofone
- CAS NO.:31848-01-8
- Empirical Formula: C21H24ClNO5
- Molecular Weight: 405.87
- EINECS: 250-838-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-27 15:49:59
What is morclofone?
Originator
Plausitin,Carlo Erba,Italy,1975
Definition
ChEBI: Morclofone is a member of benzophenones.
Manufacturing Process
Sodium methoxide (1.2 g) in dimethylformamide (150 ml) was stirred with 3,5-dimethoxy-4'-chloro-4-hydroxybenzophenone (6 g) in dimethylformamide (50 ml), for 2 hours at 120°C. The reaction mixture was then treated with β- morpholinoethyl chloride (3.4 g) and heated for 1 hour at 140C, then evaporated to dryness, and treated with water to give a solid material. The mixture was filtered, washed and crystallized from cyclohexane to give 3,5- dimethoxy-4'-chloro-4-(β-morpholinoethoxy)-benzophenone (6.5 g), MP 91°C to 92°C. The product was then reacted at about 0°C with gaseous hydrogen chloride in ether to give, after crystallization from isopropanol, the corresponding hydrochloride which had a MP of 187.9°C.
Therapeutic Function
Antitussive
Properties of morclofone
Melting point: | 91-92° |
Boiling point: | 563.1±50.0 °C(Predicted) |
Density | 1.220±0.06 g/cm3(Predicted) |
pka | 6.28±0.10(Predicted) |
Safety information for morclofone
Computed Descriptors for morclofone
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