PTP1B-IN-2
- CAS NO.：1919853-46-5
- Empirical Formula: C34H36N2O9S2
- Molecular Weight: 680.79
- Update Date: 2024-11-19 23:02:33
What is PTP1B-IN-2?
Biological Activity
PTP1B-IN-2 (MDK3465, Ptp1B-In-2, Compound P6) is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B) with IC50 of 50 nM. It enhances insulin-mediated phosphorylation of insulin receptor beta (IRβ) and insulin-stimulated glucose uptake.
in vitro
PTP1B-IN-2 displays more than 40-fold selectivity for PTP1B over SHP-2 and LAR and 15-fold higher selectivity for PTP1B over the highly homologous TCPTP.
Properties of PTP1B-IN-2
| Boiling point: | 813.4±75.0 °C(Predicted) |
| Density | 1.350±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: insol; PBS (pH 7.2): insol |
| form | A solid |
| pka | -3.81±0.50(Predicted) |
| color | White to off-white |
Safety information for PTP1B-IN-2
Computed Descriptors for PTP1B-IN-2
New Products
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