N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- CAS NO.：381168-77-0
- Empirical Formula: C19H12F2N4
- Molecular Weight: 334.32
- Update Date: 2024-11-12 15:22:20
What is N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine?
Biological Activity
ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.
in vitro
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.
Western Blot Analysis
< table class="zh_use_1">Properties of N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
| storage temp. | Store at -20°C |
| solubility | DMSO: ≥ 125 mg/mL (373.89 mM) |
| form | Solid |
| color | Light yellow to yellow |
Safety information for N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
Computed Descriptors for N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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