N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
- CAS NO.:381168-77-0
- Empirical Formula: C19H12F2N4
- Molecular Weight: 334.32
- Update Date: 2024-07-02 08:54:58
What is N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine?
Biological Activity
ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.
in vitro
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.
Western Blot Analysis
< table class="zh_use_1">Properties of N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
storage temp. | Store at -20°C |
solubility | DMSO: ≥ 125 mg/mL (373.89 mM) |
form | Solid |
color | Light yellow to yellow |
Safety information for N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
Computed Descriptors for N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
New Products
Tubulysin G Tubulysin B 2,2-diethoxyethanethioamide 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 4,4-DIFLUOROPIPERIDINE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropanol 4-(Benzyloxy)-3-bromophenylacetic Acid 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carboxylic acid 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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