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HomeProduct name listMITRAGYNINE PICRATE

MITRAGYNINE PICRATE

  • CAS NO.:4098-40-2
  • Empirical Formula: C23H30N2O4
  • Molecular Weight: 398.5
  • MDL number: MFCD00189432
  • EINECS: 200-659-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-07-21 14:17:16
MITRAGYNINE PICRATE Structural

What is MITRAGYNINE PICRATE?

Description

This alkaloid has been isolated from Mitragyna speciosa Korth, and is amorphous although it yields a series of crystalline salts and derivatives. The hydrochloride crystallizes as colourless leaflets from EtOH-Et20 with m.p. 243°C; the picrate forms thin, orange-red needles, m.p. 223-4°C and the methiodide is a pale yellow powder which, although amorphous, has a sharp melting point of 21 1. 5°C. The alkaloid also forms compounds with acetic acid, m.p. 142°C, decomposing at 175-6°, and with trichloroacetic acid, m.p. 157°C.
Mitragynine exerts a general depressant effect on plain muscle and facilitates the passage of autonomic impulses. It is, however, ineffective against pathogenic organisms.

Description

Mitragynine is the predominant alkaloid produced by the southeastern Asian plant?Mitragyna speciosa?Korth., a member of the coffee family (Rubiaceae). It was isolated in 1921 by Ellen Field, a medicinal chemist at the University of Edinburgh.
M. speciosa, known locally as kratom, has been used in traditional medicine for ≈200 years. It has opiate-like properties and has been used to treat chronic pain and opioid withdrawal symptoms. More recently, it has come into recreational use. Clinical studies on kratom and mitragynine are just beginning.
In September 2016, the US Drug Enforcement Administration (DEA)?designated kratom, mitragynine, and one of its derivatives as Schedule I substances. Schedule 1 is the most restrictive category under the US Controlled Substances Act. DEA cited the lack of information on mitragynine and reports of adverse reactions—even death—from taking kratom.
Researchers studying the medical use of mitragynine and its pseudoindoxyl derivative decried the Schedule I classification. One of them, Andrew C. Kruegel at Columbia University, said, “Placing these compounds into Schedule I will erect an enormous barrier to scientific research in this field and will dramatically curtail our work with this exciting plant.”

Chemical properties

White to Off-White Solid

The Uses of MITRAGYNINE PICRATE

A neurochemical, having both stimulant and opiate-like effects depending on the dosage. Currently, Mitragynin is being investigated for its ability to treat hard drug addiction.

The Uses of MITRAGYNINE PICRATE

Mitragynine is a neurochemical, having both stimulant and opiate-like effects depending on the dosage. Currently, Mitragynine is being investigated for its ability to treat hard drug addiction.

Definition

ChEBI: Mitragynine is a monoterpenoid indole alkaloid.

References

Field., J. Chern. Soc., 119,887 (1921)
Raymond-Hamet, Millat., Bull. sci. pharrnacol., 40, 593 (1933)
lng, Raison., J. Chern. Soc., 986 (1939)
Loudon., Chern. Soc. Spec. Publ., 3, 12 (1955)
Hendrickson., Chern. & Ind., 713 (1961)
Joshi, Raymond-Hamet, Taylor., ibid, 573 (1963)
Pharmacology: Grewal., J. Pharrn. expo Ther., 46,251 (1932)

Properties of MITRAGYNINE PICRATE

Melting point: 92-95°C
Boiling point: bp5 230-240°
alpha  D +39° (chloroform)
Density  1.22±0.1 g/cm3 (20 ºC 760 Torr)
Flash point: 9℃
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka 18.35±0.60(Predicted)
color  Light Orange to Dark Beige to Very Dark Yellow

Safety information for MITRAGYNINE PICRATE

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H225:Flammable liquids
H370:Specific target organ toxicity, single exposure
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P311:Call a POISON CENTER or doctor/physician.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for MITRAGYNINE PICRATE

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