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HomeProduct name listMICROCRYSTALLINE WAX

MICROCRYSTALLINE WAX

  • CAS NO.:63231-60-7
  • Empirical Formula: unspecified
  • Molecular Weight: 0
  • MDL number: MFCD00675940
  • EINECS: 264-038-1
  • Update Date: 2024-12-18 14:07:02

What is MICROCRYSTALLINE WAX?

Chemical properties

Microcrystalline wax occurs as odorless and tasteless waxy lumps or flakes containing small irregularly shaped crystals. It may vary in color from white to yellow, amber, brown, or black depending on the grade of material; pharmaceutical grades are usually white or yellow.
The USP32–NF27 describes microcrystalline wax as a mixture of straight-chain, branched-chain, and cyclic hydrocarbons, obtained by solvent fractionation of the still-bottom fraction of petroleum by suitable means of dewaxing or de-oiling.

Production Methods

Microcrystalline wax is obtained by solvent fractionation of the still-bottom fraction of petroleum by suitable dewaxing or deoiling.

Definition

MICROCRYSTALLINE WAX is a complex combination of long, branched chain hydrocarbons obtained from residual oils by solvent crystallization. It consists predominantly of saturated straight and branched chain hydrocarbons predominantly greater than C35.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Microcrystalline wax is used mainly as a stiffening agent in topical creams and ointments.
The wax is used to modify the crystal structure of other waxes (particularly paraffin wax) present in a mixture so that changes in crystal structure, usually exhibited over a period of time, do not occur. Microcrystalline wax also minimizes the sweating or bleeding of oils from blends of oils and waxes. Microcrystalline wax generally has a higher melting point than paraffin wax, and higher viscosity when molten, thereby increasing the consistency of creams and ointments when incorporated into such formulations.
Microcrystalline wax is also used in oral controlled-release matrix pellet formulations for various active compounds and as a tablet- and capsule-coating agent. In controlled-release systems, microcrystalline wax coatings can also be used to affect the release of drug from ion-exchange resin beads.
Microcrystalline wax is also used in confectionery, cosmetics, and food products.

Safety

Microcrystalline wax is mainly used in topical pharmaceutical formulations but is also used in some oral products. It is generally regarded as a nontoxic and nonirritating material.

storage

Microcrystalline wax is stable in the presence of acids, alkalis, light, and air. The bulk material should be stored in a well-closed container in a cool, dry place.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral capsules; topical and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Properties of MICROCRYSTALLINE WAX

solubility  Soluble in benzene, chloroform, and ether; slightly soluble in ethanol; practically insoluble in water. When melted, microcrystalline wax is miscible with volatile oils and most warm fixed oils.
Odor at 100.00?%. odorless
EPA Substance Registry System Microcrystalline paraffin waxes and hydrocarbon waxes (63231-60-7)

Safety information for MICROCRYSTALLINE WAX

Computed Descriptors for MICROCRYSTALLINE WAX

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