metipranolol
- CAS NO.:22664-55-7
- Empirical Formula: C17H27NO4
- Molecular Weight: 309.4
- MDL number: MFCD00864567
- EINECS: 245-151-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:04
What is metipranolol?
The Uses of metipranolol
Antihypertensive (β-blocker, ophthalmic).
Indications
Indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open angle glaucoma.
Background
A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.
Definition
ChEBI: 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angl glaucoma.
brand name
OptiPranolol (Bausch & Lomb Pharmaceuticals).
Pharmacokinetics
Metipranolol is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Metipranolol is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Metipranolol, when applied topically to the eye, has the action of reducing elevated, as well as normal, intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of glaucomatous visual field loss and optic nerve damage. Metipranolol reduces intraocular pressure with little or no effect on pupil size or accommodation in contrast to the miosis which cholinergic agents are known to produce.
Metabolism
Not Available
Properties of metipranolol
Melting point: | 105-107℃ |
Boiling point: | 458.7±45.0 °C(Predicted) |
Density | 1.068 |
storage temp. | 4°C, protect from light |
solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml |
form | A crystalline solid |
pka | 13.91±0.20(Predicted) |
color | White to off-white |
Safety information for metipranolol
Computed Descriptors for metipranolol
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
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