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HomeProduct name listmetipranolol

metipranolol

  • CAS NO.:22664-55-7
  • Empirical Formula: C17H27NO4
  • Molecular Weight: 309.4
  • MDL number: MFCD00864567
  • EINECS: 245-151-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 08:55:04
metipranolol Structural

What is metipranolol?

The Uses of metipranolol

Antihypertensive (β-blocker, ophthalmic).

Indications

Indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open angle glaucoma.

Background

A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent.

Definition

ChEBI: 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angl glaucoma.

brand name

OptiPranolol (Bausch & Lomb Pharmaceuticals).

Pharmacokinetics

Metipranolol is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Metipranolol is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Metipranolol, when applied topically to the eye, has the action of reducing elevated, as well as normal, intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of glaucomatous visual field loss and optic nerve damage. Metipranolol reduces intraocular pressure with little or no effect on pupil size or accommodation in contrast to the miosis which cholinergic agents are known to produce.

Metabolism

Not Available

Properties of metipranolol

Melting point: 105-107℃
Boiling point: 458.7±45.0 °C(Predicted)
Density  1.068
storage temp.  4°C, protect from light
solubility  DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form  A crystalline solid
pka 13.91±0.20(Predicted)
color  White to off-white

Safety information for metipranolol

Computed Descriptors for metipranolol

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