CHEMICAL AND PHYSICAL PROPERTIES
Physical Description | Solid |
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Melting Point | 105-107 °C |
Solubility | 589 mg/L |
LogP | 2.66 |
Dissociation Constants | 9.54 |
COMPUTED DESCRIPTORS
Molecular Weight | 309.4 g/mol |
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XLogP3 | 2.7 |
Hydrogen Bond Donor Count | 2 |
Hydrogen Bond Acceptor Count | 5 |
Rotatable Bond Count | 8 |
Exact Mass | 309.19400834 g/mol |
Monoisotopic Mass | 309.19400834 g/mol |
Topological Polar Surface Area | 67.8 Ų |
Heavy Atom Count | 22 |
Formal Charge | 0 |
Complexity | 348 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently-Bonded Unit Count | 1 |
Compound Is Canonicalized | Yes |
PRODUCT INTRODUCTION
description
Metipranolol is 3-(Propan-2-ylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is substituted by a 4-acetoxy-2,3,5-trimethylphenoxy group. A non-cardioselective beta-blocker, it is used to lower intra-ocular pressure in the management of open-angle glaucoma. It has a role as a beta-adrenergic antagonist, an anti-arrhythmia drug, an antihypertensive agent and an antiglaucoma drug. It is a propanolamine, an acetate ester, an aromatic ether and a secondary amino compound.