metiazinic acid
- CAS NO.：13993-65-2
- Empirical Formula: C15H13NO2S
- Molecular Weight: 271.33
- MDL number: MFCD00866023
- EINECS: 2377950
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is metiazinic acid ?
Originator
Soripan,Specia,France,1970
Definition
ChEBI: Phenothiazine substituted at nitrogen by a methyl group and at C-2 by a carboxymethyl group.
Manufacturing Process
10-Methyl-3-acetylphenthiazine is prepared in accordance with G. Cauquil and A. Casadevall, Bull. Soc.Chim., p 768 (1955). (10-Methyl-3-phenthiazinyl)acetic acid (MP 146°C; 21.4 g) is prepared by Willgerodt's reaction (action of sulfur and morpholine, followed by hydrolysis) employing 10-methyl-3-acetylphenthiazine as starting material.
Therapeutic Function
Antiinflammatory
Trade name
Roimal (Kantoishi, Japan), Soripal (Torii, Japan).
Synthesis
Metiazinic acid is prepared via
the Willgerodt reaction (sulfur and morpholine)
from 2-acetyl-10-methylphenothiazine.
Dosage
Metiazinic acid has been beneficial to arthritis patients when given at a daily dose of 0.75 – 1.5 g/d.
Properties of metiazinic acid
| Melting point: | 146° |
| Boiling point: | 482.6±44.0 °C(Predicted) |
| Density | 1.2237 (rough estimate) |
| refractive index | 1.7500 (estimate) |
| pka | 4.12±0.10(Predicted) |
| Water Solubility | 31mg/L(30 ºC) |
Safety information for metiazinic acid
Computed Descriptors for metiazinic acid
New Products
TIN AAS SOLUTION SILVER AAS SOLUTION ANDRADES REAGENT SOLUTION GRAMS SAFRANINE STAINING SOLUTION PLATINUM AAS SOLUTION TUNGSTEN AAS SOLUTION Folic Acid Impurity G Desloratidine Related compound B Dabigatran Acyl-O2-D-Glucuronide Trifluoroacetic Acid Salt Eltrombopag N-Oxide Impurity Di-Nitroso Acyclovir Impurity K DLRD N-OxideRelated products of tetrahydrofuran
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