metiazinic acid
- CAS NO.：13993-65-2
- Empirical Formula: C15H13NO2S
- Molecular Weight: 271.33
- MDL number: MFCD00866023
- EINECS: 2377950
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is metiazinic acid ?
Originator
Soripan,Specia,France,1970
Definition
ChEBI: Phenothiazine substituted at nitrogen by a methyl group and at C-2 by a carboxymethyl group.
Manufacturing Process
10-Methyl-3-acetylphenthiazine is prepared in accordance with G. Cauquil and A. Casadevall, Bull. Soc.Chim., p 768 (1955). (10-Methyl-3-phenthiazinyl)acetic acid (MP 146°C; 21.4 g) is prepared by Willgerodt's reaction (action of sulfur and morpholine, followed by hydrolysis) employing 10-methyl-3-acetylphenthiazine as starting material.
Therapeutic Function
Antiinflammatory
Trade name
Roimal (Kantoishi, Japan), Soripal (Torii, Japan).
Synthesis
Metiazinic acid is prepared via
the Willgerodt reaction (sulfur and morpholine)
from 2-acetyl-10-methylphenothiazine.
Dosage
Metiazinic acid has been beneficial to arthritis patients when given at a daily dose of 0.75 – 1.5 g/d.
Properties of metiazinic acid
| Melting point: | 146° |
| Boiling point: | 482.6±44.0 °C(Predicted) |
| Density | 1.2237 (rough estimate) |
| refractive index | 1.7500 (estimate) |
| pka | 4.12±0.10(Predicted) |
| Water Solubility | 31mg/L(30 ºC) |
Safety information for metiazinic acid
Computed Descriptors for metiazinic acid
New Products
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