4-MERCAPTOPHENYLACETIC ACID

CAS NO.：39161-84-7
Empirical Formula: C8H8O2S
Molecular Weight: 168.21
MDL number: MFCD00797617
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:40

What is 4-MERCAPTOPHENYLACETIC ACID?

Chemical properties

4-MERCAPTOPHENYLACETIC ACID is White Powder

The Uses of 4-MERCAPTOPHENYLACETIC ACID

4-MERCAPTOPHENYLACETIC ACID is a redox buffer that increases the folding rate of disulfide-containing proteins realative to traditional buffers such as glutathione and glutathione-disulfide. A useful synthetic intermediate for the preparation of novel antiinflammatory agents.

The Uses of 4-MERCAPTOPHENYLACETIC ACID

4-Mercaptophenylacetic acid has been used in the preparation of small ubiquitin-like modifier peptides from bis(2-sulfanylethyl)amido peptide via sequential native chemical ligation.
It can be used:

On-resin preparation of peptide-^α thiophenylesters which are used in a chemical ligation process for the chemical synthesis of peptides.
In one pot deprotection of (acetamido-methyl)cysteine following native chemical ligation and/or desulfurization method for the preparation of peptides.
Palladium facilitated deprotection of N-terminal cysteine through native chemical ligation method for the preparation of synthetically challenging proteins.

What are the applications of Application

4-Mercaptophenylacetic Acid is a redox buffer that increases the folding rate of disulfide-containing proteins

Properties of 4-MERCAPTOPHENYLACETIC ACID

Melting point:	105-109 °C (lit.)
Boiling point:	336.0±17.0 °C(Predicted)
Density	1.299±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Acetonitrile (Slightly), DMSO (Slightly)
pka	4.21±0.10(Predicted)
form	Solid
color	Off-White
Water Solubility	Slightly soluble in water. Soluble in Dichloromethane, Ethanol and Methanol
Sensitive	Air Sensitive

Safety information for 4-MERCAPTOPHENYLACETIC ACID

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.