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HomeProduct name listMethylglyoxal 1,1-dimethyl acetal

Methylglyoxal 1,1-dimethyl acetal

Synonym(s):1,1-Dimethoxyacetone;Pyruvaldehyde-1-dimethyl acetal;Pyruvic aldehyde dimethyl acetal

  • CAS NO.:6342-56-9
  • Empirical Formula: C5H10O3
  • Molecular Weight: 118.13
  • MDL number: MFCD00008758
  • EINECS: 228-735-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-24 21:11:45
Methylglyoxal 1,1-dimethyl acetal Structural

What is Methylglyoxal 1,1-dimethyl acetal?

Chemical properties

clear colorless to yellow liquid

The Uses of Methylglyoxal 1,1-dimethyl acetal

Methylglyoxal 1,1-dimethyl acetal was used in the synthesis of methylglyoxal via hydrolysis in the presence of H2SO4. It was used to investigate the effects of methylglyoxal-mediated glycation on the structure, thermal stability and enzyme activity of yeast enolase in vivo.

The Uses of Methylglyoxal 1,1-dimethyl acetal

Pyruvic Aldehyde Dimethyl Acetal is used in the preparation of MCL1 inhibitors S63845 which is tolerable and effective in diverse cancer models. Also, acts as a synthetic reagent for the preparation of 8novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Selective inhibition of neuronal nitric oxide synthase is an important therapeutic approach to target neurodegenerative disorders.

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 2642, 1976 DOI: 10.1021/jo00877a030

Properties of Methylglyoxal 1,1-dimethyl acetal

Melting point: -57 °C
Boiling point: 143-147 °C(lit.)
Density  0.976 g/mL at 25 °C(lit.)
vapor pressure  11hPa at 20℃
refractive index  n20/D 1.398(lit.)
Flash point: 100 °F
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
form  Liquid
color  Clear colorless to yellow
Water Solubility  MISCIBLE
BRN  1560557
CAS DataBase Reference 6342-56-9
NIST Chemistry Reference 2-Propanone, 1,1-dimethoxy-(6342-56-9)
EPA Substance Registry System 2-Propanone, 1,1-dimethoxy- (6342-56-9)

Safety information for Methylglyoxal 1,1-dimethyl acetal

Signal word Warning
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H226:Flammable liquids
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Methylglyoxal 1,1-dimethyl acetal

InChIKey ULVSHNOGEVXRDR-UHFFFAOYSA-N

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