Methylglyoxal 1,1-dimethyl acetal
Synonym(s):1,1-Dimethoxyacetone;Pyruvaldehyde-1-dimethyl acetal;Pyruvic aldehyde dimethyl acetal
- CAS NO.:6342-56-9
- Empirical Formula: C5H10O3
- Molecular Weight: 118.13
- MDL number: MFCD00008758
- EINECS: 228-735-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-24 21:11:45
What is Methylglyoxal 1,1-dimethyl acetal?
Chemical properties
clear colorless to yellow liquid
The Uses of Methylglyoxal 1,1-dimethyl acetal
Methylglyoxal 1,1-dimethyl acetal was used in the synthesis of methylglyoxal via hydrolysis in the presence of H2SO4. It was used to investigate the effects of methylglyoxal-mediated glycation on the structure, thermal stability and enzyme activity of yeast enolase in vivo.
The Uses of Methylglyoxal 1,1-dimethyl acetal
Pyruvic Aldehyde Dimethyl Acetal is used in the preparation of MCL1 inhibitors S63845 which is tolerable and effective in diverse cancer models. Also, acts as a synthetic reagent for the preparation of 8novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Selective inhibition of neuronal nitric oxide synthase is an important therapeutic approach to target neurodegenerative disorders.
Synthesis Reference(s)
The Journal of Organic Chemistry, 41, p. 2642, 1976 DOI: 10.1021/jo00877a030
Properties of Methylglyoxal 1,1-dimethyl acetal
Melting point: | -57 °C |
Boiling point: | 143-147 °C(lit.) |
Density | 0.976 g/mL at 25 °C(lit.) |
vapor pressure | 11hPa at 20℃ |
refractive index | n |
Flash point: | 100 °F |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
form | Liquid |
color | Clear colorless to yellow |
Water Solubility | MISCIBLE |
BRN | 1560557 |
CAS DataBase Reference | 6342-56-9 |
NIST Chemistry Reference | 2-Propanone, 1,1-dimethoxy-(6342-56-9) |
EPA Substance Registry System | 2-Propanone, 1,1-dimethoxy- (6342-56-9) |
Safety information for Methylglyoxal 1,1-dimethyl acetal
Signal word | Warning |
Pictogram(s) |
Flame Flammables GHS02 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methylglyoxal 1,1-dimethyl acetal
InChIKey | ULVSHNOGEVXRDR-UHFFFAOYSA-N |
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