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HomeProduct name listMethyl (triphenylphosphoranylidene)acetate

Methyl (triphenylphosphoranylidene)acetate

Synonym(s):(Carbomethoxymethylene)triphenylphosphorane;(Methoxycarbonylmethylene)triphenylphosphorane

  • CAS NO.:2605-67-6
  • Empirical Formula: C21H19O2P
  • Molecular Weight: 334.35
  • MDL number: MFCD00008455
  • EINECS: 220-018-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-07-27 13:57:03
Methyl (triphenylphosphoranylidene)acetate Structural

What is Methyl (triphenylphosphoranylidene)acetate?

Chemical properties

white to off-white powder

The Uses of Methyl (triphenylphosphoranylidene)acetate

  1. (Methoxycarbonylmethylene)triphenylphosphorane is used in olefination reactions. Wittig reagent for the two-carbon homologation of aldehydes to α,β-unsaturated esters. it undergoes the Wittig reaction with aldehydes to give substituted methyl acrylates.
  2. used in an efficient synthesis of pyrazoles via reaction with methyl diazoacetate in the presence of triethylamine.
  3. It is used in the preparation of (triphenylphosphoranylidene)-ketene.
  4. The Wittig reaction we performed in class involved the reaction of 2-nitrobenzaldehyde (1) with methyl (triphenylphosphoranylidene) acetate (2) to produce methyl (2E)-3-(2-nitrophenyl) acrylate (3) with a triphenylphosphine oxide (4) side product, and took place in a silica gel matrix to ensure even product dispersion for chromatography.
    Wittig Reaction

The Uses of Methyl (triphenylphosphoranylidene)acetate

(Methoxycarbonylmethylene)triphenylphosphorane is used in olefination reactions. Further, it undergoes the Wittig reaction with aldehydes to give substituted methyl acrylates. It is used in the preparation of (triphenylphosphoranylidene)-ketene.

The Uses of Methyl (triphenylphosphoranylidene)acetate

Wittig reagent for the two-carbon homologation of aldehydes to α,β-unsaturated esters. Also used in an efficient synthesis of pyrazoles via reaction with methyl diazoacetate in the presence of triethylamine.

Purification Methods

Crystallise it by dissolving in it AcOH and adding pet ether (b 40-50o) to give colourless plates. UV max (A 1mm ): 222nm (865) and 268nm (116) [Isler et al. Helv Chim Acta 40 1242 1957]. [Beilstein 16 IV 977.]

Properties of Methyl (triphenylphosphoranylidene)acetate

Melting point: 168-172 °C (lit.)
Boiling point: 165~170℃
Density  1.17±0.1 g/cm3(Predicted)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Acetonitrile (Slightly), Chloroform (Slightly)
form  Powder
color  White to off-white
Water Solubility  insoluble
Sensitive  Air Sensitive
BRN  618430
CAS DataBase Reference 2605-67-6(CAS DataBase Reference)
EPA Substance Registry System Acetic acid, (triphenylphosphoranylidene)-, methyl ester (2605-67-6)

Safety information for Methyl (triphenylphosphoranylidene)acetate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Methyl (triphenylphosphoranylidene)acetate

InChIKey NTNUDYROPUKXNA-UHFFFAOYSA-N

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