Methyl (triphenylphosphoranylidene)acetate
Synonym(s):(Carbomethoxymethylene)triphenylphosphorane;(Methoxycarbonylmethylene)triphenylphosphorane
- CAS NO.:2605-67-6
- Empirical Formula: C21H19O2P
- Molecular Weight: 334.35
- MDL number: MFCD00008455
- EINECS: 220-018-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-27 13:57:03
What is Methyl (triphenylphosphoranylidene)acetate?
Chemical properties
white to off-white powder
The Uses of Methyl (triphenylphosphoranylidene)acetate
- (Methoxycarbonylmethylene)triphenylphosphorane is used in olefination reactions. Wittig reagent for the two-carbon homologation of aldehydes to α,β-unsaturated esters. it undergoes the Wittig reaction with aldehydes to give substituted methyl acrylates.
- used in an efficient synthesis of pyrazoles via reaction with methyl diazoacetate in the presence of triethylamine.
- It is used in the preparation of (triphenylphosphoranylidene)-ketene.
- The Wittig reaction we performed in class involved the reaction of 2-nitrobenzaldehyde (1) with methyl (triphenylphosphoranylidene) acetate (2) to produce methyl (2E)-3-(2-nitrophenyl) acrylate (3) with a triphenylphosphine oxide (4) side product, and took place in a silica gel matrix to ensure even product dispersion for chromatography.
The Uses of Methyl (triphenylphosphoranylidene)acetate
(Methoxycarbonylmethylene)triphenylphosphorane is used in olefination reactions. Further, it undergoes the Wittig reaction with aldehydes to give substituted methyl acrylates. It is used in the preparation of (triphenylphosphoranylidene)-ketene.
The Uses of Methyl (triphenylphosphoranylidene)acetate
Wittig reagent for the two-carbon homologation of aldehydes to α,β-unsaturated esters. Also used in an efficient synthesis of pyrazoles via reaction with methyl diazoacetate in the presence of triethylamine.
Purification Methods
Crystallise it by dissolving in it AcOH and adding pet ether (b 40-50o) to give colourless plates. UV max (A 1mm ): 222nm (865) and 268nm (116) [Isler et al. Helv Chim Acta 40 1242 1957]. [Beilstein 16 IV 977.]
Properties of Methyl (triphenylphosphoranylidene)acetate
Melting point: | 168-172 °C (lit.) |
Boiling point: | 165~170℃ |
Density | 1.17±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | Acetonitrile (Slightly), Chloroform (Slightly) |
form | Powder |
color | White to off-white |
Water Solubility | insoluble |
Sensitive | Air Sensitive |
BRN | 618430 |
CAS DataBase Reference | 2605-67-6(CAS DataBase Reference) |
EPA Substance Registry System | Acetic acid, (triphenylphosphoranylidene)-, methyl ester (2605-67-6) |
Safety information for Methyl (triphenylphosphoranylidene)acetate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methyl (triphenylphosphoranylidene)acetate
InChIKey | NTNUDYROPUKXNA-UHFFFAOYSA-N |
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product: Methyl(triphenylphosphoranylidene) acetate 2605-67-6 99%
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Methyl (triphenylphosphoranylidene)acetate
AURORA KA-1059
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