Methyl cyanoacetate
- CAS NO.:105-34-0
- Empirical Formula: C4H5NO2
- Molecular Weight: 99.09
- MDL number: MFCD00001939
- EINECS: 203-288-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-21 15:02:05
What is Methyl cyanoacetate?
Chemical properties
clear colorless to very slighlty yellow liquid
The Uses of Methyl cyanoacetate
Methyl cyanoacetate is an intermediate in the preparation of α-cyanoacrylate, malononitrile, 1,1-cyclohexanediacetic acid dye. It is used as UV absorber or stabiliser, intermediate for pharmaceuticals. It may be used in the synthesis of various 1,2,5-tricarbonyl compounds.
The Uses of Methyl cyanoacetate
pharmaceutical intermediate
Definition
ChEBI: Methyl cyanoacetate is an alkyl cyanoacetate ester.
General Description
Methyl cyanoacetate is the intermediate product in pharmaceutical organic synthesis as well as in the synthesis of some biologically active compounds used in agriculture. It undergoes calcite or fluorite catalyzed Kn?venagel condensation with aromatic aldehydes, giving the corresponding arylidenemalononitriles and (E)-α-cyanocinnamic esters.
Purification Methods
Purify the ester by shaking with 10% Na2CO3 solution, wash well with water, dry with anhydrous Na2SO4, and distil it. [Beilstein 2 H 584, 2 I 253, 2 II 530, 2 III 1628, 2 IV 1889.]
Properties of Methyl cyanoacetate
Melting point: | -13 °C |
Boiling point: | 204-207 °C(lit.) |
Density | 1.123 g/mL at 25 °C(lit.) |
vapor density | 3.41 (vs air) |
vapor pressure | 0.2 mm Hg ( 20 °C) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Sealed in dry,Room Temperature |
solubility | 54g/l |
form | Liquid |
pka | 2.75±0.10(Predicted) |
color | Clear colorless to very slightly yellow |
Water Solubility | 54 g/L (20 ºC) |
Sensitive | Light Sensitive |
BRN | 773945 |
Dielectric constant | 29.4(21℃) |
CAS DataBase Reference | 105-34-0(CAS DataBase Reference) |
NIST Chemistry Reference | Acetic acid, cyano-, methyl ester(105-34-0) |
EPA Substance Registry System | Acetic acid, cyano-, methyl ester (105-34-0) |
Safety information for Methyl cyanoacetate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Methyl cyanoacetate
Abamectin manufacturer
Rivashaa Agrotech Biopharma Pvt. Ltd.
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