Methyl phenoxyacetate
- CAS NO.:2065-23-8
- Empirical Formula: C9H10O3
- Molecular Weight: 166.17
- MDL number: MFCD00010227
- EINECS: 218-176-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-12 17:26:57
What is Methyl phenoxyacetate?
Chemical properties
Methyl phenoxyacetate, when the temperature ≥ 30°C is a clear colorless to slightly yellow liquid; at < 30°C is a white solid. It can be used as disinfectant or pharmaceutical intermediate or pesticide intermediate.
The Uses of Methyl phenoxyacetate
Methyl phenoxyacetate (MPOA) was used as an acylating agent in the synthesis of loracarbef, a carbacephalosporin antibiotic.
Preparation
synthesis of methyl phenoxyacetate: methyl bromoacetate (10 mL, 105.6 mmol) and phenol (9.9380 g, 105.6 mmol) were dissolved in 250 mL of acetone; K2CO3 (21.89 g, 158 mmol) and KI (5 g, 30 mmol) were added and the mixture heated to reflux with stirring overnight. The mixture was filtered and the resultant solution concentrated in vacuo. Deionized water (200 mL) was added. The reaction mixture was extracted with 50 mL ethyl acetate three times. The combined ethyl acetate layers were washed with brine, dried over MgSO4, and filtered. All ethyl acetate was removed in vacuo, resulting in a slightly yellow liquid (80% yield).
Properties of Methyl phenoxyacetate
Melting point: | 245 °C |
Boiling point: | 243 °C (lit.) |
Density | 1.149 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Sealed in dry,Room Temperature |
form | clear liquid |
Specific Gravity | 1.149 |
color | Colorless to Light orange to Yellow |
CAS DataBase Reference | 2065-23-8(CAS DataBase Reference) |
NIST Chemistry Reference | Acetic acid, phenoxy-, methyl ester(2065-23-8) |
EPA Substance Registry System | Acetic acid, phenoxy-, methyl ester (2065-23-8) |
Safety information for Methyl phenoxyacetate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methyl phenoxyacetate
InChIKey | BZCKRPHEZOHHBK-UHFFFAOYSA-N |
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