Methyl methanesulfonate

Chemical properties

colourless liquid

Chemical properties

Clear, colorless to amber liquid.

The Uses of Methyl methanesulfonate

Methyl methanesulfonate is a DNA adduct that adds methyl groups to Dan at 7-guanine, 3-guanine and 3-adenine.

The Uses of Methyl methanesulfonate

Experimentally as mutagen, teratogen, brain carcinogen.

What are the applications of Application

Methyl methanesulfonate is a DNA adduct that adds methyl groups to Dna at 7-guanine, 3-guanine and 3-adenine

Definition

ChEBI: A methanesulfonate ester resulting from the formal condensation of methanesulfonic acid with methanol.

General Description

Colorless to amber liquid.

Air & Water Reactions

Water soluble.

Reactivity Profile

Methyl methanesulfonate is incompatible with strong oxidizing agents, strong acids and strong bases.

Fire Hazard

Methyl methanesulfonate is combustible.

Safety Profile

Confirmed carcinogen with carcinogenic and neoplastigenic data. Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human mutation data reported. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of SOx.

Potential Exposure

Research chemical and cancer drug. No longer produced commercially in the United States.

Carcinogenicity

Methyl methanesulfonate is reascarcinogen based on sufficient evi onably anticipated to be a human dence of carcinogenicity from studies in experimental animals.

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

Purify the ester by careful fractionation and collecting the middle fraction. Suspected CARCINOGEN. Note that MeSO3H has b 167-167.5o/10mm and methanesulfonic anhydride has b 138o/10mm)—both are possible impurities. [Beilstein 4 IV 11.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition

Waste Disposal

It is inappropriate and possibly dangerous to the environment to dispose of lab chemicals or expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged, and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.