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HomeProduct name listMETHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE

METHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE

METHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE Structural

What is METHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE?

The Uses of METHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE

Methyl 7-Methoxy-2H-indazole-3-carboxylate is an intermediate in the synthesis of 7-Hydroxy Granisetron (H942675), a metabolite of Granisetron (G780000), a specific serotonin (5HT3) receptor antagonist. Used as an antiemetic. Granisetron HCl is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve. It does not have much effect on vomiting due to motion sickness. This drug does not have any effect on dopamine receptors or muscarinic receptor.

Properties of METHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE

Melting point: 141-142 °C
Boiling point: 382.2±22.0 °C(Predicted)
Density  1.313±0.06 g/cm3(Predicted)
pka 11.26±0.40(Predicted)

Safety information for METHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for METHYL 7-METHOXY-1H-INDAZOLE-3-CARBOXYLATE

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