Methyl 3-hydroxypropanoate
- CAS NO.：6149-41-3
- Empirical Formula: C4H8O3
- Molecular Weight: 104.1
- MDL number: MFCD00272293
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-01-03 09:50:41
What is Methyl 3-hydroxypropanoate?
Definition
ChEBI: 2-Methyl-3-hydroxypropanoate is a 3-hydroxy carboxylic acid.
General Description
Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Properties of Methyl 3-hydroxypropanoate
| Melting point: | 147-148 °C(Solv: benzene (71-43-2); cyclohexane (110-82-7)) |
| Boiling point: | 179°C (estimate) |
| Density | 1.1050 |
| refractive index | 1.4300 |
| storage temp. | 2-8°C |
| solubility | Chloroform, Methanol |
| form | Oil |
| pka | 13.89±0.10(Predicted) |
| color | Colourless |
| InChI | InChI=1S/C4H8O3/c1-7-4(6)2-3-5/h5H,2-3H2,1H3 |
Safety information for Methyl 3-hydroxypropanoate
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for Methyl 3-hydroxypropanoate
| InChIKey | RVGLEPQPVDUSOJ-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)CCO |
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