Methyl 3-hydroxypropanoate

CAS NO.：6149-41-3
Empirical Formula: C4H8O3
Molecular Weight: 104.1
MDL number: MFCD00272293
SAFETY DATA SHEET (SDS)
Update Date: 2024-01-03 09:50:41

What is Methyl 3-hydroxypropanoate?

Definition

ChEBI: 2-Methyl-3-hydroxypropanoate is a 3-hydroxy carboxylic acid.

General Description

Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Properties of Methyl 3-hydroxypropanoate

Melting point:	147-148 °C(Solv: benzene (71-43-2); cyclohexane (110-82-7))
Boiling point:	179°C (estimate)
Density	1.1050
refractive index	1.4300
storage temp.	2-8°C
solubility	Chloroform, Methanol
form	Oil
pka	13.89±0.10(Predicted)
color	Colourless
InChI	InChI=1S/C4H8O3/c1-7-4(6)2-3-5/h5H,2-3H2,1H3

Safety information for Methyl 3-hydroxypropanoate

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool.