Methyl 3-amino-4-methylthiophene-2-carboxylate
Synonym(s):3-Amino-4-methylthiophenecarboxylic acid methyl ester
- CAS NO.：85006-31-1
- Empirical Formula: C7H9NO2S
- Molecular Weight: 171.22
- MDL number: MFCD00051822
- EINECS: 285-060-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 15:18:15
What is Methyl 3-amino-4-methylthiophene-2-carboxylate?
Chemical properties
white to light yellow crystal powder
The Uses of Methyl 3-amino-4-methylthiophene-2-carboxylate
Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B.
Definition
ChEBI: Methyl 3-amino-4-methylthiophene-2-carboxylate is a thiophenecarboxylic acid.
Methyl 3-amino-4-methylthiophene-2-carboxylate Application
methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine.7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate.The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield.
Properties of Methyl 3-amino-4-methylthiophene-2-carboxylate
| Melting point: | 85-88 °C (lit.) |
| Boiling point: | 318.6±37.0 °C(Predicted) |
| Density | 1.264±0.06 g/cm3(Predicted) |
| Flash point: | >100°C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 1.71±0.10(Predicted) |
| color | Pale Yellow |
| Water Solubility | 1g/L at 35℃ |
| BRN | 973196 |
| CAS DataBase Reference | 85006-31-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1) |
Safety information for Methyl 3-amino-4-methylthiophene-2-carboxylate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Methyl 3-amino-4-methylthiophene-2-carboxylate
| InChIKey | YICRPERKKBDRSP-UHFFFAOYSA-N |
Methyl 3-amino-4-methylthiophene-2-carboxylate manufacturer
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