Methyl 3-amino-2-pyrazinecarboxylate

CAS NO.：16298-03-6
Empirical Formula: C6H7N3O2
Molecular Weight: 153.14
MDL number: MFCD00010097
EINECS: 240-387-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is Methyl 3-amino-2-pyrazinecarboxylate?

Chemical properties

yellow crystalline powder

The Uses of Methyl 3-amino-2-pyrazinecarboxylate

Methyl 3-amino-2-pyrazinecarboxylate has been used in:

synthesis of 2-arylpteridin-4-ones and piperazine-derived 2-furan-2-yl-[1,2,4]triazolo[1,5-a] pyrazines
reactions with isocyanates and aroyl chlorides for conversion to pteridinediones

Definition

ChEBI: Methyl 3-aminopyrazine-2-carboxylate is a pyrazine that is substituted by a methoxycarbonyl group at position 2 and an amino group at position 3. It is a member of pyrazines, a methyl ester and an aromatic amine.

Purification Methods

The ester forms yellow needles from H2O (100 parts using charcoal). If it contains the free acid (see IR), then dissolve it in CH2Cl2, wash it with saturated aqueous Na2CO3, brine, dry over MgSO4 filter, evaporate and recrystallise the residue. The free acid has m 203-204o (dec) [UV: Brown & Mason J Chem Soc 3443 1956] and pK1 <1 and pK2 3.70. The ammonium salt has m 232o(dec) (from aqueous Me2CO) and the amide has m 239.2o (from H2O) [Ellingson et al. J Am Chem Soc 67 1711 1945]. [Beilstein 25 III/IV 4412.]

Properties of Methyl 3-amino-2-pyrazinecarboxylate

Melting point:	169-172 °C (lit.)
Boiling point:	300.8±37.0 °C(Predicted)
Density	1.319±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	Chloroform, Methanol
form	Crystalline Powder
pka	-0.30±0.10(Predicted)
color	Yellow
BRN	127495
CAS DataBase Reference	16298-03-6(CAS DataBase Reference)

Safety information for Methyl 3-amino-2-pyrazinecarboxylate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.