Methyl 3-amino-2-pyrazinecarboxylate
- CAS NO.：16298-03-6
- Empirical Formula: C6H7N3O2
- Molecular Weight: 153.14
- MDL number: MFCD00010097
- EINECS: 240-387-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is Methyl 3-amino-2-pyrazinecarboxylate?
Chemical properties
yellow crystalline powder
The Uses of Methyl 3-amino-2-pyrazinecarboxylate
Methyl 3-amino-2-pyrazinecarboxylate has been used in:
- synthesis of 2-arylpteridin-4-ones and piperazine-derived 2-furan-2-yl-[1,2,4]triazolo[1,5-a] pyrazines
- reactions with isocyanates and aroyl chlorides for conversion to pteridinediones
Definition
ChEBI: Methyl 3-aminopyrazine-2-carboxylate is a pyrazine that is substituted by a methoxycarbonyl group at position 2 and an amino group at position 3. It is a member of pyrazines, a methyl ester and an aromatic amine.
Purification Methods
The ester forms yellow needles from H2O (100 parts using charcoal). If it contains the free acid (see IR), then dissolve it in CH2Cl2, wash it with saturated aqueous Na2CO3, brine, dry over MgSO4 filter, evaporate and recrystallise the residue. The free acid has m 203-204o (dec) [UV: Brown & Mason J Chem Soc 3443 1956] and pK1 <1 and pK2 3.70. The ammonium salt has m 232o(dec) (from aqueous Me2CO) and the amide has m 239.2o (from H2O) [Ellingson et al. J Am Chem Soc 67 1711 1945]. [Beilstein 25 III/IV 4412.]
Properties of Methyl 3-amino-2-pyrazinecarboxylate
| Melting point: | 169-172 °C (lit.) |
| Boiling point: | 300.8±37.0 °C(Predicted) |
| Density | 1.319±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Chloroform, Methanol |
| form | Crystalline Powder |
| pka | -0.30±0.10(Predicted) |
| color | Yellow |
| BRN | 127495 |
| CAS DataBase Reference | 16298-03-6(CAS DataBase Reference) |
Safety information for Methyl 3-amino-2-pyrazinecarboxylate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for Methyl 3-amino-2-pyrazinecarboxylate
| InChIKey | INCSQLZZXBPATR-UHFFFAOYSA-N |
Methyl 3-amino-2-pyrazinecarboxylate manufacturer
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