Methyl 2,5-dihydroxybenzoate

Synonym(s):Methyl gentisate

CAS NO.：2150-46-1
Empirical Formula: C8H8O4
Molecular Weight: 168.15
MDL number: MFCD00016464
EINECS: 218-427-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-14 19:04:07

What is Methyl 2,5-dihydroxybenzoate?

The Uses of Methyl 2,5-dihydroxybenzoate

Methyl 2,5-dihydroxybenzoate (methyl gentisate) may be used as a starting material in the synthesis of euonyminol.

The Uses of Methyl 2,5-dihydroxybenzoate

methyl gentisate is also known as methyl dihydroxybenzoate. It is a skin-lightening ingredient that acts by inhibiting the melanocyte’s production of tyrosinase. It can be naturally obtained from gentian root.

Definition

ChEBI: Methyl 2,5-dihydroxybenzoate is a member of phenols and a benzoate ester.

General Description

Methyl 2,5-dihydroxybenzoate (methyl gentisate) is an alkyl ester of gentisic acid. It is reported to show less cytotoxic and mutagenic activity than hydroquinone with a potential to inhibit melanogenesis. It has been synthesized from 2,5-dihydroxybenzoic acid. The crystal structure of the molecule was found to be planar.

Properties of Methyl 2,5-dihydroxybenzoate

Melting point:	86-88 °C (lit.)
Boiling point:	136 °C / 1mmHg
Density	1.354±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.87±0.18(Predicted)
color	Off-White to Pale Beige
Stability:	Hygroscopic
CAS DataBase Reference	2150-46-1(CAS DataBase Reference)
NIST Chemistry Reference	Benzoic acid, 2,5-dihydroxy-, methyl ester(2150-46-1)

Safety information for Methyl 2,5-dihydroxybenzoate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.