METHIOTHEPIN MALEATE

CAS NO.：20229-30-5
Empirical Formula: C20H24N2S2
Molecular Weight: 356.55
MDL number: MFCD00209930
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is METHIOTHEPIN MALEATE?

The Uses of METHIOTHEPIN MALEATE

Methiothepin Maleate exhibits anticonvulsant property and it is able to suppress pentylenetetrazol induced fos expression in zebrafish. In addition, Methiothepin Maleate is a 5-HT antagonist.

The Uses of METHIOTHEPIN MALEATE

5HT1&2 receptor antagonist

Definition

ChEBI: Methiothepin is a dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). It has a role as an antipsychotic agent, a dopaminergic antagonist, a serotonergic antagonist and a geroprotector. It is a N-alkylpiperazine, a dibenzothiepine, an aryl sulfide and a tertiary amino compound. It is a conjugate base of a methiothepin(2+).

Biological Activity

Potent 5-HT 2 antagonist, also active as 5-HT 1 antagonist. Differentiates 5-HT 1D sub-types. Also displays affinity for rodent 5-HT 5B , 5-HT 5A , 5-HT 7 and 5-HT 6 receptors (pK 1 values are 6.6, 7.0, 8.4 and 8.7 respectively).

Properties of METHIOTHEPIN MALEATE

Melting point:	88-89°
Boiling point:	462.9±45.0 °C(Predicted)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	H₂O: 13 mg/mL
form	solid
pka	7.95±0.42(Predicted)
color	white