Methacetin

CAS NO.：51-66-1
Empirical Formula: C9H11NO2
Molecular Weight: 165.19
MDL number: MFCD00014963
EINECS: 200-114-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:15:30

What is Methacetin?

Chemical properties

LIGHT BEIGE CRYSTALLINE POWDER

The Uses of Methacetin

Methacetin is evaluated in a breath test to predict early liver disfunction due to valproic acid and other cause. Methacetin breath test (MBT) is a rapid, non-invasive assessment of liver function in acute severe liver disease and a potential key tool in future dignosis.

Definition

ChEBI: Methacetin is a member of the class of acetamides that is paracetamol in which the hydrogen of phenolic hydroxy group has been replaced by a methyl group. It is a member of acetamides and an aromatic ether. It is functionally related to a p-anisidine and a paracetamol.

Synthesis Reference(s)

Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061
The Journal of Organic Chemistry, 42, p. 3755, 1977
Organic Syntheses, Coll. Vol. 3, p. 661, 1955

Safety Profile

Moderately toxic by ingestion andother unspecified routes. When heated to decomposition itemits toxic fumes of NOx.

Properties of Methacetin

Melting point:	128-130 °C(lit.)
Boiling point:	293.03°C (rough estimate)
Density	1.1603 (rough estimate)
refractive index	1.5839 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	14.53±0.70(Predicted)
form	Crystalline
color	White
Water Solubility	0.42 g/100 mL (20 ºC)
Merck	14,51
BRN	387887
Stability:	Hygroscopic
CAS DataBase Reference	51-66-1(CAS DataBase Reference)
NIST Chemistry Reference	N-(4-Methoxyphenyl)acetic acid amide(51-66-1)
EPA Substance Registry System	Acetamide, N-(4-methoxyphenyl)- (51-66-1)

Safety information for Methacetin

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P501:Dispose of contents/container to..…