Metaxalone
Synonym(s):Metaxalone;Metazalone;Metazolone;5-(3,5-Dimethylphenoxymethyl)-2-oxazolidinone;5-[(3,5-Xylyloxy)methyl]-2-oxazolidinone
- CAS NO.:1665-48-1
- Empirical Formula: C12H15NO3
- Molecular Weight: 221.25
- MDL number: MFCD00867700
- EINECS: 216-777-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-15 18:41:30
What is Metaxalone?
Absorption
The absolute bioavailability of metaxalone from Skelaxin tablets is not known.
Toxicity
LD50=775mg/kg (Rat, oral); LD50=1690 mg/kg (Mouse, oral). When determining the LD50 in rats and mice, progressive sedation, hypnosis and finally respiratoryfailure were noted as the dosage increased. In dogs, no LD50 could be determined as the higher doses produced an emetic action in 15 to 30 minutes. Some adverse events associated with the drug include nausea, vomiting, drowsiness and CNS side effects such as dizziness, headache, and irritability.
The Uses of Metaxalone
Metaxalone is a skeletal muscle relaxant that has applications in reducing muscle spasm, limitations in normal motion, and pain caused by musculoskeletal conditions. It is commonly used in combination with analgesics to address low back pain. The molecular or cellular actions of metaxalone is not known.[Cayman Chemical]
Background
Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin?. Its main mechanism of action is thought to involve general central nervous system depression. Metaxalone is associated with few side effects and is available as a 800 mg scored tablet.
Indications
For the treatment of painful peripheral musculoskeletal conditions and spasticity from upper motor neuron syndromes.
What are the applications of Application
Metaxalone is which may act as a general central nervous system depressant
Pharmacokinetics
Metaxalone is a skeletal muscle relaxant indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Metaxalone does not directly relax tense skeletal muscles in man.
Metabolism
Probably hepatic.
Properties of Metaxalone
Melting point: | 121-1230C |
Boiling point: | 225°C/1.5mmHg(lit.) |
Density | 1.1514 (rough estimate) |
Flash point: | 9 °C |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | DMSO: ≥2mg/mL (warmed to 60 °C) |
form | powder |
color | white to tan |
Safety information for Metaxalone
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for Metaxalone
InChIKey | IMWZZHHPURKASS-UHFFFAOYSA-N |
Abamectin manufacturer
TYNDAL LABS PVT LTD
Vasoya Industries Pvt Ltd
Ralington Pharma
Raks Pharma Pvt Ltd
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