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HomeProduct name listMeptazinol hydrochloride

Meptazinol hydrochloride

Synonym(s):3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-phenol hydrochloride;IL-22811 hydrochloride;WY-22811 hydrochloride

  • CAS NO.:59263-76-2
  • Empirical Formula: C15H24ClNO
  • Molecular Weight: 269.81
  • MDL number: MFCD00941476
  • EINECS: 261-683-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Meptazinol hydrochloride Structural

What is Meptazinol hydrochloride?

Description

Meptazinol hydrochloride is an injectable narcotic analgesic with antagonist properties; it is similar in potency to meperidine. Meptazinol appears to have a low propensity toward respiratory depression and other opiate-like side effects, possibly due to selective interaction with the mu-1 receptor. Also somewhat unique for an analgesic, it interacts with central cholinergic receptors. An oral form of meptazinol is under development.

Chemical properties

White Solid

Originator

Wyeth (United Kingdom)

The Uses of Meptazinol hydrochloride

Analgesic;Opiate receptor agonist

The Uses of Meptazinol hydrochloride

Mixed opioid agonist-antagonist. Analgesic (narcotic).

brand name

MEPTID

Biological Activity

Centrally active opioid analgesic. Partial agonist at the μ 1 opioid receptor. Also shown to inhibit acetylcholinesterase.

Biochem/physiol Actions

Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic. Its pharmacology is not completely understood; however, its analgesic properties are mostly due to its partial agonism at the mu1 opioid receptor. Due to its partial agonism, Meptazinol antagonizes morphine dependence in vivo. Its advantage over other opiates is its reduced capacity to cause addition and respiratory depression, also due to its intrinsic activity as a partial agonist. Meptazinol has been found to have additional activity as an acetylcholinesterase (AChE) inhibitor, particularly in its (-) enantiomeric form, which may partially explain its analgesic properties. AChE inhibitors are used to treat Alzheimer′s disease, providing additional interest in this compound.

Properties of Meptazinol hydrochloride

Melting point: 250-252°C
storage temp.  Inert atmosphere,2-8°C
solubility  H2O: >10mg/mL
form  powder
color  white to off-white
Stability: Hygroscopic

Safety information for Meptazinol hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P501:Dispose of contents/container to..…

Computed Descriptors for Meptazinol hydrochloride

InChIKey MPJUSISYVXABBH-UHFFFAOYSA-N

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