Meptazinol hydrochloride
Synonym(s):3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-phenol hydrochloride;IL-22811 hydrochloride;WY-22811 hydrochloride
- CAS NO.:59263-76-2
- Empirical Formula: C15H24ClNO
- Molecular Weight: 269.81
- MDL number: MFCD00941476
- EINECS: 261-683-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 20:33:22
What is Meptazinol hydrochloride?
Description
Meptazinol hydrochloride is an injectable narcotic analgesic with antagonist properties; it is similar in potency to meperidine. Meptazinol appears to have a low propensity toward respiratory depression and other opiate-like side effects, possibly due to selective interaction with the mu-1 receptor. Also somewhat unique for an analgesic, it interacts with central cholinergic receptors. An oral form of meptazinol is under development.
Chemical properties
White Solid
Originator
Wyeth (United Kingdom)
The Uses of Meptazinol hydrochloride
Analgesic;Opiate receptor agonist
The Uses of Meptazinol hydrochloride
Mixed opioid agonist-antagonist. Analgesic (narcotic).
brand name
MEPTID
Biological Activity
Centrally active opioid analgesic. Partial agonist at the μ 1 opioid receptor. Also shown to inhibit acetylcholinesterase.
Biochem/physiol Actions
Meptazinol entered the human pharmaceutical market as a racemic mixture in the 1980s for use as an analgesic. Its pharmacology is not completely understood; however, its analgesic properties are mostly due to its partial agonism at the mu1 opioid receptor. Due to its partial agonism, Meptazinol antagonizes morphine dependence in vivo. Its advantage over other opiates is its reduced capacity to cause addition and respiratory depression, also due to its intrinsic activity as a partial agonist. Meptazinol has been found to have additional activity as an acetylcholinesterase (AChE) inhibitor, particularly in its (-) enantiomeric form, which may partially explain its analgesic properties. AChE inhibitors are used to treat Alzheimer′s disease, providing additional interest in this compound.
Properties of Meptazinol hydrochloride
Melting point: | 250-252°C |
storage temp. | Inert atmosphere,2-8°C |
solubility | H2O: >10mg/mL |
form | powder |
color | white to off-white |
Stability: | Hygroscopic |
Safety information for Meptazinol hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P501:Dispose of contents/container to..… |
Computed Descriptors for Meptazinol hydrochloride
InChIKey | MPJUSISYVXABBH-UHFFFAOYSA-N |
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