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HomeProduct name listMeclizine Dihydrochloride Monohydrate

Meclizine Dihydrochloride Monohydrate

  • CAS NO.:31884-77-2
  • Empirical Formula: C25H27ClN2.2ClH.H2O
  • Molecular Weight: 481.892
  • MDL number: MFCD00941489
  • EINECS: 688-525-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:37
Meclizine Dihydrochloride Monohydrate Structural

What is Meclizine Dihydrochloride Monohydrate?

Chemical properties

White Solid

Originator

Antivert,Roerig,US,1957

The Uses of Meclizine Dihydrochloride Monohydrate

Meclizine Dihydrochloride Monohydrate is used for the prevention and treatment of nausea, vomiting, or dizziness associated with motion sickness.

The Uses of Meclizine Dihydrochloride Monohydrate

Antiemetic and H1-histamine receptor antagonistMeclizine dihydrochloride monohydrate acts as an antiemetic. It is also used for the prevention and treatment of nausea during pregnancy. In addition to this, it is used in radiation sickness, vomiting or dizziness associated with motion sickness. Product purchased here is only for use in Research and Development.

What are the applications of Application

Meclizine Dihydrochloride Monohydrate is an antiemetic

Definition

ChEBI: Meclizine hydrochloride is a diarylmethane.

Manufacturing Process

32.3 g of 1-p-chlorobenzhydryl-4-benzyl-piperazine, dissolved in 300 cm3 of alcohol are heated in an autoclave vessel, in the presence of Raney nickel, under a pressure of 100 kg H2, at about 150°C for 6 hours. The catalyst is filtered, the solvent is evaporated and the residue is fractionated under a high vacuum. p-Chlorobenzylhydryl-piperazine (BP 180° to 185°C/1 mm Hg) is isolated with a yield of 75%. Then finely ground NaNH2 is added. The mixture is heated under reflux for 1 hour, the mass is cooled and a molar equivalent of m-methyl benzyl chloride is added.
The solvent is evaporated and the residue is dissolved in chloroform. This solution is washed with a saturated solution of K2CO3 and dried on K2CO3. The solvent is evaporated and the residue is distilled under high vacuum. The product of the condensation distills near 230°C at 2 mm Hg pressure and the corresponding dihydrochloride melts at 217° to 224°C.

brand name

Antivert (Pfizer).

Therapeutic Function

Antinauseant

General Description

Meclizine hydrochloride,1-(p-chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazinedihydrochloride monohydrate (Bonine, Antivert), is atasteless, white or slightly yellowish crystalline powder that is practically insoluble in water (1:1,000). It differs fromchlorcyclizine in having an N-m-methylbenzyl group inplace of the N-methyl group. Although it is a moderately potentantihistaminic, meclizine is used primarily as an antinauseantin the prevention and treatment of motion sicknessand in the treatment of nausea and vomiting associated withvertigo.

Properties of Meclizine Dihydrochloride Monohydrate

Melting point: 210-213°C
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form  Solid
color  White
Water Solubility  Insoluble in water.
CAS DataBase Reference 31884-77-2

Safety information for Meclizine Dihydrochloride Monohydrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H361:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313:IF exposed or concerned: Get medical advice/attention.
P405:Store locked up.

Computed Descriptors for Meclizine Dihydrochloride Monohydrate

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