Mandelic acid

Synonym(s):(R)-(-)-Mandelic acid;DL-Mandelic acid;D-Mandelic acid, D-α-Hydroxyphenylacetic acid;Racemic mandelic acid;(R)-α-Hydroxyphenylacetic acid

CAS NO.：611-71-2
Empirical Formula: C8H8O3
Molecular Weight: 152.15
MDL number: MFCD00064251
EINECS: 210-276-6
SAFETY DATA SHEET (SDS)
Update Date: 2025-03-06 17:06:57

What is Mandelic acid?

Definition

ChEBI: (R)-mandelic acid is the (R)-enantiomer of mandelic acid. It has a role as a human xenobiotic metabolite. It is a conjugate acid of a (R)-mandelate. It is an enantiomer of a (S)-mandelic acid.

Synthesis Reference(s)

The Journal of Organic Chemistry, 33, p. 2565, 1968 DOI: 10.1021/jo01270a105
Synthetic Communications, 18, p. 2141, 1988 DOI: 10.1080/00397918808068285

Safety

Mandelic acid is a great AHA option for all skin types but is a particularly wonderful option for sensitive skin due to its gentle nature.

Sources

Mandelic acid is an exfoliating alpha hydroxy acid (AHA) that may be derived from bitter almonds or synthetically created.

The Uses of Mandelic acid

Mandelic acid benefits skin primarily through exfoliation. Like other AHAs, it works to loosen the bonds between skin cells, allowing dead, dull cells to slough off and in the process, reveals radiant, healthy skin.

Properties of Mandelic acid

Melting point:	131-133 °C(lit.)
Boiling point:	214.6°C (rough estimate)
alpha	-150 º (c=2.5, H2O)
Density	1.1677 (rough estimate)
refractive index	-153.5 ° (C=1, H2O)
Flash point:	>190℃
storage temp.	Store below +30°C.
solubility	109.8g/l soluble
form	Crystalline Powder, Crystals or Flakes
pka	3.37(at 25℃)
color	White to slightly yellow-beige
PH	3.34(1 mM solution);2.75(10 mM solution);2.22(100 mM solution);
optical activity	[α]25/D 151°, c = 1 in ethanol
Water Solubility	It is partly soluble in water, freely soluble in isopropyl and ethyl alcohol.
Sensitive	Light Sensitive
BRN	2691094
Stability:	Stable, but light sensitive. Combustible. Incompatible with strong bases, strong oxidizing agents.
CAS DataBase Reference	611-71-2(CAS DataBase Reference)
EPA Substance Registry System	Benzeneacetic acid, .alpha.-hydroxy-, (.alpha.R)- (611-71-2)

Safety information for Mandelic acid

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.