m-PEG10-amine
- CAS NO.：1383658-09-0
- Empirical Formula: C21H45NO10
- Molecular Weight: 471.58
- MDL number: MFCD27977522
- Update Date: 2024-03-27 13:09:27
What is m-PEG10-amine?
Description
m-PEG10-amine is reactive with activated NHS esters to form stable aminde bond. The hydrophilic PEG spacer increases solubility in aqueous media.
Biological Activity
m-PEG10-amine is a non-cleavable ADC linker containing 10 units of PEG, which can be used for the synthesis of antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Properties of m-PEG10-amine
| Boiling point: | 518.9±45.0 °C(Predicted) |
| Density | 1.065±0.06 g/cm3(Predicted) |
| pka | 8.74±0.10(Predicted) |
Safety information for m-PEG10-amine
Computed Descriptors for m-PEG10-amine
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